Section on Nephrology, Bowman Gray School of Medicine, Winston-Salem, North Carolina (M.V.R.); Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania (N.H.S.); and Department of Medicine/Nephrology, School of Osteopathic Medicine, University of Medicine and Dentistry of New Jersey, Stratford, New Jersey (R.K.K.).
J Clin Rheumatol. 1996 Jun;2(3):160-2. doi: 10.1097/00124743-199606000-00010.
We present the first reported case of a patient who developed de novo systemic lupus erythematosus (SLE) after the initiation of dialysis for chronic renal failure. The etiology of his renal failure was secondary to biopsy-proven idiopathic membranoproliferative glomerulonephritis in conjunction with accelerated hypertension. The physical, biochemical or serologic findings of SLE did not become apparent until 4 years after the initiation of hemodialysis. This deviates from the natural history of SLE; typically, once dialysis is initiated, disease and serologic activity diminish with time to the point where therapy is no longer required. Therefore, this first diagnosis of SLE after years on dialysis represents a novel observation.
我们报告了首例患者在开始透析治疗慢性肾衰竭后新发系统性红斑狼疮（SLE）的病例。他的肾衰竭病因是活检证实的特发性膜增生性肾小球肾炎合并加速性高血压。SLE 的身体、生化或血清学发现直到开始血液透析 4 年后才变得明显。这与 SLE 的自然病程不同；通常，一旦开始透析，疾病和血清学活动随时间减少，以至于不再需要治疗。因此，在透析多年后首次诊断为 SLE 是一个新的观察结果。
