Kawahara K, Storb R, Sanders J, Petersen F B
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98104.
Blood. 1991 Aug 15;78(4):1140-3.
We report the case of a 6.5-year-old male who received an unrelated orthotopic liver transplant for hepatic failure and encephalopathy following non-A-non-B hepatitis and subsequently developed severe aplastic anemia. For treatment of his aplastic anemia, he received a successful marrow transplant from his 9-year-old genotypically HLA-identical sister following conditioning with cyclophosphamide 200 mg/kg and anti-thymocyte globulin 90 mg/kg. Significant veno-occlusive disease of the liver and graft-versus-host disease did not occur. The patient remains alive without clinical chronic active hepatitis or need for blood product therapy. His hematocrit is 36%, white blood cell count 9.7 x 10(3)/mm3, and platelet count 1.7 x 10(5)/mm3 almost 2 years after marrow transplantation.
我们报告了一例6.5岁男性患者，该患者因非甲非乙型肝炎后肝衰竭和脑病接受了非亲属原位肝移植，随后发展为严重再生障碍性贫血。为治疗其再生障碍性贫血，在接受200 mg/kg环磷酰胺和90 mg/kg抗胸腺细胞球蛋白预处理后，他成功接受了来自其9岁基因型HLA匹配姐姐的骨髓移植。未发生严重的肝静脉闭塞病和移植物抗宿主病。患者存活，无临床慢性活动性肝炎，也无需血液制品治疗。骨髓移植近2年后，他的血细胞比容为36%，白细胞计数为9.7×10³/mm³，血小板计数为1.7×10⁵/mm³。
