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位置，位置，还是位置：肠道固有层中的B细胞分化

Location, location, location: B-cell differentiation in the gut lamina propria.

作者信息

Cerutti A

机构信息

Department of Pathology and Laboratory Medicine, Weill Medical College, Cornell University, New York, New York, USA.

出版信息

Mucosal Immunol. 2008 Jan;1(1):8-10. doi: 10.1038/mi.2007.8.

DOI:10.1038/mi.2007.8
PMID:19079155
Abstract

The intestinal immune system includes an immunoglobulin (Ig)A-inductive site represented by Peyer's patches (PPs) and an IgA effector site represented by the lamina propria (LP). This canonical map of intestinal IgA production has been blurred recently by studies showing the presence of active IgA class switching in the LP. Here we discuss the functional implications and controversial nature of these findings.

摘要

肠道免疫系统包括以派尔集合淋巴结（PPs）为代表的免疫球蛋白（Ig）A诱导部位和以固有层（LP）为代表的IgA效应部位。最近的研究表明固有层中存在活跃的IgA类别转换，这一经典的肠道IgA产生图谱已变得模糊不清。在此，我们讨论这些发现的功能意义及争议性。

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