Ding Mengfan, Li Bowen, Chen Haiqin, Ross Reynolds Paul, Stanton Catherine, Zhao Jianxin, Chen Wei, Yang Bo
State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China.
School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Nutrients. 2024 Apr 12;16(8):1148. doi: 10.3390/nu16081148.
Throughout infancy, IgA is crucial for maintaining gut mucosal immunity. This study aims to determine whether supplementing newborn mice with eight different strains of subsp. might regulate their IgA levels. The strains were gavaged to BALB/C female ( = 8) and male ( = 8) dams at 1-3 weeks old. Eight strains of subsp. had strain-specific effects in the regulation of intestinal mucosal barriers. B6MNI, I4MI, and I10TI can increase the colonic IgA level in females and males. I8TI can increase the colonic IgA level in males. B6MNI was also able to significantly increase the colonic sIgA level in females. B6MNI, I4MI, I8TI, and I10TI regulated colonic and Peyer's patch IgA synthesis genes but had no significant effect on IgA synthesis pathway genes in the jejunum and ileum. Moreover, the variety of sIgA-coated bacteria in male mice was changed by I4MI, I5TI, I8TI, and B6MNI. These strains also can decrease the relative abundance of . These results indicate that subsp. can promote IgA levels but show strain specificity. Different dietary habits with different strains of may have varying effects on IgA levels when supplemented in early infancy.
在整个婴儿期，IgA对于维持肠道黏膜免疫至关重要。本研究旨在确定用八种不同亚种菌株补充新生小鼠是否会调节它们的IgA水平。这些菌株在1至3周龄时通过灌胃给予BALB/C雌性（n = 8）和雄性（n = 8）母鼠。八种亚种菌株在调节肠道黏膜屏障方面具有菌株特异性作用。B6MNI、I4MI和I10TI可增加雌性和雄性小鼠的结肠IgA水平。I8TI可增加雄性小鼠的结肠IgA水平。B6MNI还能够显著增加雌性小鼠的结肠sIgA水平。B6MNI、I4MI、I8TI和I10TI调节结肠和派尔集合淋巴结的IgA合成基因，但对空肠和回肠的IgA合成途径基因没有显著影响。此外，I4MI、I5TI、I8TI和B6MNI改变了雄性小鼠中sIgA包被细菌的种类。这些菌株还可降低[具体细菌名称]的相对丰度。这些结果表明，亚种菌株可促进IgA水平，但具有菌株特异性。在婴儿早期补充不同菌株的[具体物质名称]时，不同的饮食习惯可能对IgA水平产生不同影响。
