肠道上皮细胞中的IKK/NF-κB信号传导控制肠道内的免疫稳态。

IKK/NF-kappaB signaling in intestinal epithelial cells controls immune homeostasis in the gut.

作者信息

Pasparakis M

机构信息

Institute for Genetics, University of Cologne, Cologne, Germany.

出版信息

Mucosal Immunol. 2008 Nov;1 Suppl 1:S54-7. doi: 10.1038/mi.2008.53.

DOI:10.1038/mi.2008.53

PMID:19079232

Abstract

The intestinal epithelium regulates the interaction between commensal bacteria and the immune system not only by providing a physical barrier but also by expressing a number of immunoregulatory and antimicrobial peptides. Recent studies showed that inhibition of IkappaB kinase (IKK)/nuclear factor-kappaB (NF-kappaB) signaling specifically in intestinal epithelial cells in vivo causes the spontaneous development of intestinal inflammation in mice. These findings identify IKK/NF-kappaB signaling in intestinal epithelial cells as an important factor for the maintenance of epithelial integrity and immune homeostasis in the gut.

摘要

肠道上皮不仅通过提供物理屏障，还通过表达多种免疫调节和抗菌肽来调节共生细菌与免疫系统之间的相互作用。最近的研究表明，在体内特异性抑制肠道上皮细胞中的IκB激酶（IKK）/核因子-κB（NF-κB）信号传导会导致小鼠肠道炎症的自发发展。这些发现表明，肠道上皮细胞中的IKK/NF-κB信号传导是维持肠道上皮完整性和免疫稳态的重要因素。