Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, China.
The People's Hospital of Danyang, Affiliated Danyang Hospital of Nantong University, Zhenjiang, Jiangsu, China.
Front Immunol. 2023 Oct 23;14:1284133. doi: 10.3389/fimmu.2023.1284133. eCollection 2023.
Inflammation is a characteristic symptom of the occurrence and development of many diseases, which is mainly characterized by the infiltration of inflammatory cells such as macrophages and granulocytes, and the increased release of proinflammatory factors. Subsequently, macrophage differentiates and T cells and other regulated factors exhibit anti-inflammatory function, releasing pro- and anti-inflammatory factors to maintain homeostasis. Although reports define various degrees of metabolic disorders in both the inflamed and non-inflamed parts of inflammatory diseases, little is known about the changes in amino acid metabolism in such conditions. This review aims to summarize amino acid changes and mechanisms involved in the progression of inflammatory bowel disease (IBD) and other inflammatory diseases. Since mesenchymal stem cells (MSCs) and their derived exosomes (MSC-EXO) have been found to show promising effects in the treatment of IBD and other inflammatory diseases,their potential in the modulation of amino acid metabolism in the treatment of inflammation is also discussed.
炎症是许多疾病发生和发展的一个特征症状，主要表现为巨噬细胞和粒细胞等炎性细胞的浸润，以及促炎因子的大量释放。随后，巨噬细胞分化，T 细胞和其他调节因子表现出抗炎功能，释放促炎和抗炎因子以维持平衡。尽管有报道定义了炎症性疾病的炎症和非炎症部分存在不同程度的代谢紊乱，但对这种情况下氨基酸代谢的变化知之甚少。本综述旨在总结炎症性肠病 (IBD) 和其他炎症性疾病中氨基酸变化及其机制。由于间充质干细胞 (MSC) 及其衍生的外泌体 (MSC-EXO) 已被发现对 IBD 和其他炎症性疾病的治疗具有良好的效果，因此还讨论了它们在调节氨基酸代谢治疗炎症中的潜在作用。
