全基因组关联研究在七个与肥胖指标相关的基因座上发现了新的序列变异。
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.
作者信息
Thorleifsson Gudmar, Walters G Bragi, Gudbjartsson Daniel F, Steinthorsdottir Valgerdur, Sulem Patrick, Helgadottir Anna, Styrkarsdottir Unnur, Gretarsdottir Solveig, Thorlacius Steinunn, Jonsdottir Ingileif, Jonsdottir Thorbjorg, Olafsdottir Elinborg J, Olafsdottir Gudridur H, Jonsson Thorvaldur, Jonsson Frosti, Borch-Johnsen Knut, Hansen Torben, Andersen Gitte, Jorgensen Torben, Lauritzen Torsten, Aben Katja K, Verbeek André L M, Roeleveld Nel, Kampman Ellen, Yanek Lisa R, Becker Lewis C, Tryggvadottir Laufey, Rafnar Thorunn, Becker Diane M, Gulcher Jeffrey, Kiemeney Lambertus A, Pedersen Oluf, Kong Augustine, Thorsteinsdottir Unnur, Stefansson Kari
机构信息
deCODE Genetics, Reykjavik, Iceland.
出版信息
Nat Genet. 2009 Jan;41(1):18-24. doi: 10.1038/ng.274. Epub 2008 Dec 14.
Obesity results from the interaction of genetic and environmental factors. To search for sequence variants that affect variation in two common measures of obesity, weight and body mass index (BMI), both of which are highly heritable, we performed a genome-wide association (GWA) study with 305,846 SNPs typed in 25,344 Icelandic, 2,998 Dutch, 1,890 European Americans and 1,160 African American subjects and combined the results with previously published results from the Diabetes Genetics Initiative (DGI) on 3,024 Scandinavians. We selected 43 variants in 19 regions for follow-up in 5,586 Danish individuals and compared the results to a genome-wide study on obesity-related traits from the GIANT consortium. In total, 29 variants, some correlated, in 11 chromosomal regions reached a genome-wide significance threshold of P < 1.6 x 10(-7). This includes previously identified variants close to or in the FTO, MC4R, BDNF and SH2B1 genes, in addition to variants at seven loci not previously connected with obesity.
肥胖是由遗传和环境因素相互作用导致的。为了寻找影响肥胖的两个常见指标（体重和体重指数（BMI），这两个指标都具有高度遗传性）变异的序列变体，我们对25344名冰岛人、2998名荷兰人、1890名欧裔美国人以及1160名非裔美国人进行了全基因组关联（GWA）研究，共检测了305846个单核苷酸多态性（SNP），并将结果与糖尿病遗传计划（DGI）之前发表的关于3024名斯堪的纳维亚人的研究结果相结合。我们在19个区域选择了43个变体，在5586名丹麦个体中进行后续研究，并将结果与GIANT联盟关于肥胖相关性状的全基因组研究进行比较。总共有11个染色体区域的29个变体（有些变体相互关联）达到了全基因组显著性阈值P < 1.6 x 10^(-7)。这包括先前在FTO、MC4R、BDNF和SH2B1基因附近或内部发现的变体，以及七个先前未与肥胖相关联的位点上的变体。
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