Lee Ga Young, Lee Junghak, Kim Jeong-Han, Chung Kyong-Mee, Han Sung Nim
Department of Food and Nutrition, College of Human Ecology, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea.
Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, Republic of Korea.
Eur J Nutr. 2025 May 27;64(5):190. doi: 10.1007/s00394-025-03713-x.
Genes associated with body mass index (BMI), including FTO rs9939609,MC4R rs17782313, and BDNF rs6265, may influence BMI and regulate energy metabolism. While previous studies have explored health-related behavior changes, few have investigated both biochemical and behavior changes resulting from perceived genetic risk. This study investigated whether recognizing BMI-related genes affects health-related behaviors and alters blood metabolite levels.
Normal and overweight adults aged 25-35 years (n = 100) were randomly assigned to an intervention group (n = 65) informed about BMI-related genetic information (FTO rs9939609, MC4R rs17782313, BDNF rs6265) and an uninformed group (n = 35, CON). The intervention group was further divided into Intervention-high risk (IHR, n = 36) and intervention-low risk (ILR, n = 29) subgroups. Dietary intake and physical activity (PA) were assessed using a 3-day dietary record and the IPAQ-short form. Blood metabolites were analyzed through multivariate analyses to identify significant differences among the groups, with measurements taken at baseline, 3 months, and 6 months.
The IHR group exhibited increased dietary fat and fast foods intake, along with enhanced vigorous and moderate PA. Six metabolites were selected as biomarkers that were distinguishable among groups, and the relative serum cholesterol levels significantly decreased in the IHR group at 3 months.
These results demonstrate that recognizing the BMI-associated genetic risk resulted in a short-term increase in PA but did not improve dietary intake. Increased PA was significantly associated with reduced cholesterol concentration, suggesting the clinical importance of physical activity in the genetically at-risk group.
This study was reviewed and approved by the Seoul National University Institutional Review Board (IRB #1901/001-004) and registered on the Clinical Research Information Service (CRIS), KCT0004650 ( https://cris.nih.go.kr/cris/search/detailSearch.do /14091, 2020/01/28).
与体重指数（BMI）相关的基因，包括FTO rs9939609、MC4R rs17782313和BDNF rs6265，可能会影响BMI并调节能量代谢。虽然先前的研究探讨了与健康相关的行为变化，但很少有研究调查感知到的遗传风险所导致的生化和行为变化。本研究调查了识别与BMI相关的基因是否会影响与健康相关的行为并改变血液代谢物水平。
将25 - 35岁的正常和超重成年人（n = 100）随机分为干预组（n = 65），该组被告知与BMI相关的遗传信息（FTO rs9939609、MC4R rs17782313、BDNF rs6265），以及未被告知的组（n = 35，CON）。干预组进一步分为干预高风险（IHR, n = 36）和干预低风险（ILR, n = 29）亚组。使用3天饮食记录和国际体力活动问卷简表评估饮食摄入量和身体活动（PA）。通过多变量分析对血液代谢物进行分析，以确定各组之间的显著差异，在基线、3个月和6个月时进行测量。
IHR组的膳食脂肪和快餐摄入量增加，同时剧烈和中等强度的PA增强。六种代谢物被选为可在各组之间区分的生物标志物，IHR组在3个月时相对血清胆固醇水平显著降低。
这些结果表明，识别与BMI相关的遗传风险会导致短期内PA增加，但不会改善饮食摄入量。PA增加与胆固醇浓度降低显著相关，表明身体活动在遗传风险组中的临床重要性。
本研究经首尔国立大学机构审查委员会审查并批准（IRB #1901/001 - 004），并在临床研究信息服务（CRIS）上注册，KCT0004650（https://cris.nih.go.kr/cris/search/detailSearch.do /14091, 2020/01/28）。
