Turyk Mary E, Persky Victoria W, Imm Pamela, Knobeloch Lynda, Chatterton Robert, Anderson Henry A
Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, 1603 W. Taylor Street, Chicago, IL 60612, USA.
Environ Health Perspect. 2008 Dec;116(12):1635-41. doi: 10.1289/ehp.11707. Epub 2008 Jul 24.
Persistent pollutants, such as polychlorinated biphenyls (PCBs), affect endocrine function. Human exposure to polybrominated diphenyl ethers (PBDEs), which are similar in structure to PCBs, has increased recently, but health effects have not been well studied.
Our goal in this study was to determine whether PBDE body burdens are related to thyroid and steroid hormone levels, thyroid antibodies, and thyroid disease in a cohort of frequent and infrequent adult male sport fish consumers.
We tested serum from 405 adult males for PBDE congeners, PCB congeners, testosterone, sex-hormone-binding globulin (SHBG), SHBG-bound testosterone, thyroglobulin antibodies, and the thyroid hormones thyroxine (T(4)), triiodothyronine (T(3)), thyroid-stimulating hormone (TSH), and T(4)-binding globulin (TBG). We collected data on demographics, fish consumption, medical diseases, and medication use.
The median sum of PBDEs was 38 ng/g lipid. In 308 men without thyroid disease or diabetes, PBDEs were positively related to measures of T(4) and reverse T(3) and inversely related to total T(3) and TSH. PBDEs were positively related to the percentage of T(4) bound to albumin, and inversely related to the percentage of T(4) bound to TBG. Associations of BDE congeners with hormones varied. BDE-47 was positively associated with testosterone levels. Participants with PBDEs over the 95th percentile were more likely to have thyroglobulin antibodies, although high PBDE exposure was not associated with thyroid disease. PBDE effects were independent of PCB exposure and sport fish consumption.
PBDE exposure, at levels comparable with those of the general U.S. population, was associated with increased thyroglobulin antibodies and increased T(4) in adult males.
多氯联苯（PCBs）等持久性污染物会影响内分泌功能。人类近期接触到的多溴二苯醚（PBDEs），其结构与多氯联苯相似，接触量有所增加，但对健康的影响尚未得到充分研究。
本研究的目的是确定在成年男性食用运动鱼类频率不同的队列中，多溴二苯醚的体内负荷是否与甲状腺激素、类固醇激素水平、甲状腺抗体及甲状腺疾病有关。
我们检测了405名成年男性血清中的多溴二苯醚同系物、多氯联苯同系物、睾酮、性激素结合球蛋白（SHBG）、与SHBG结合的睾酮、甲状腺球蛋白抗体以及甲状腺激素甲状腺素（T(4)）、三碘甲状腺原氨酸（T(3)）、促甲状腺激素（TSH）和T(4)结合球蛋白（TBG）。我们收集了有关人口统计学、鱼类消费、疾病及用药情况的数据。
多溴二苯醚的中位数总和为38 ng/g脂质。在308名无甲状腺疾病或糖尿病的男性中，多溴二苯醚与T(4)和反式T(3)的指标呈正相关，与总T(3)和TSH呈负相关。多溴二苯醚与结合白蛋白的T(4)百分比呈正相关，与结合TBG的T(4)百分比呈负相关。多溴二苯醚同系物与激素的关联各不相同。BDE-47与睾酮水平呈正相关。多溴二苯醚含量超过第95百分位数的参与者更有可能出现甲状腺球蛋白抗体，尽管高剂量多溴二苯醚暴露与甲状腺疾病无关。多溴二苯醚的影响独立于多氯联苯暴露和运动鱼类消费。
与美国普通人群相当的多溴二苯醚暴露水平与成年男性甲状腺球蛋白抗体增加及T( 4)升高有关。
