Rydholm Amber E, Held Nicole L, Bowman Christopher N, Anseth Kristi S
Chemical and Biological Engineering, University of Colorado, Boulder, CO 80309-0424.
Macromolecules. 2006 Nov 14;39(23):7882-7888. doi: 10.1021/ma060858u.
Crosslinked, degradable networks formed from the photopolymerization of thiol and acrylate monomers are explored as potential biomaterials. The degradation behavior and material properties of these networks are influenced by the molecular weight of the nondegradable thiol-polyacrylate backbone chains that form during photopolymerization. Here, gel permeation chromatography was used to characterize the thiol-polyacrylate backbone chain lengths in degraded thiol-acrylate networks. Increasing thiol functionality from 1 to 4 increased the backbone molecular weight (M̄(w) = 2.3 ± 0.07 × 10(4) Da for monothiol and 3.6 ± 0.1 × 10(4) Da for tetrathiol networks). Decreasing thiol functional group concentration from 30 to 10 mol% also increased the backbone lengths (M̄(w) = 7.3 ± 1.1 × 10(4) Da for the networks containing 10 mol% thiol groups as compared to 3.6 ± 0.1 × 10(4) Da for 30 mol% thiol). Finally, the backbone chain lengths were probed at various stages of degradation and an increase in backbone molecular weight was observed as mass loss progressed from 10 to 70%.
由硫醇和丙烯酸酯单体光聚合形成的交联、可降解网络被作为潜在生物材料进行探索。这些网络的降解行为和材料性能受光聚合过程中形成的不可降解硫醇-聚丙烯酸酯主链的分子量影响。在此，凝胶渗透色谱法用于表征降解后的硫醇-丙烯酸酯网络中硫醇-聚丙烯酸酯主链的长度。将硫醇官能度从1增加到4会增加主链分子量（单硫醇网络的M̄(w) = 2.3 ± 0.07 × 10(4) Da，四硫醇网络的M̄(w) = 3.6 ± 0.1 × 10(4) Da）。将硫醇官能团浓度从30 mol%降至10 mol%也会增加主链长度（含10 mol%硫醇基团的网络的M̄(w) = 7.3 ± 1.1 × 10(4) Da，相比之下含30 mol%硫醇的网络为3.6 ± 0.1 × 10(4) Da）。最后，在降解的各个阶段探测主链长度，随着质量损失从10%进展到70%，观察到主链分子量增加。
