Weissmann G
Division of Rheumatology, New York University School of Medicine.
Hosp Pract (Off Ed). 1991 Aug 15;26(8):60-8, 71-2, 75-6. doi: 10.1080/21548331.1991.11705279.
The ability of aspirin and related drugs to inhibit prostaglandin biosynthesis accounts for many effects of NSAIDs but does not completely explain their efficacy against inflammation. An additional mechanism may be disruption of the intracellular signal pathways responsible for activation of inflammatory cells--notably, neutrophils.