Doping Control Laboratory, Department of Clinical Biology, Microbiology and Immunology, Faculty of Medicine and Health Sciences, Ghent University - UGent, Technologiepark 30B, B-9052 Zwijnaarde, Belgium.
Nutr Res Rev. 2006 Jun;19(1):147-58. doi: 10.1079/NRR2006122.
Based upon recent sales numbers, nutritional supplements play a key role in the lifestyle of a substantial proportion of the population. As well as products such as vitamins or minerals, several precursors of anabolic steroids are marketed as nutritional supplements. Another group of commercially available supplements are products for weight loss based upon herbal formulations originating from Ephedra species. Apart from supplements indicating the presence of these active compounds, numerous non-hormonal nutritional supplements were found that were contaminated with non-labelled anabolic steroids. Stimulating agents other than naturally occurring analogues of ephedrine were detected. A major group using dietary supplements are sportsmen, ranging from amateur level to elite athletes. Besides the possible health risks associated with the use of dietary supplements, athletes should take care not to violate the rules of the World Anti-Doping Agency because athletes remain responsible for substances detected in their biofluids, irrespective of their origin. Several analytical methods have been developed to determine the presence of doping agents as contaminants. The present review attempts to address the issues concerning the use of nutritional supplements and the detection of doping agents as contaminants in dietary supplements.
基于最近的销售数据，营养补充剂在相当一部分人群的生活方式中扮演着重要角色。除了维生素或矿物质等产品外，几种合成代谢类固醇的前体也作为营养补充剂销售。另一组市售的补充剂是基于源自麻黄属植物的草药配方的减肥产品。除了表明存在这些活性化合物的补充剂外，还发现了许多未经标记的合成代谢类固醇污染的非激素类营养补充剂。除了检测到的天然类似物以外，还发现了其他刺激剂。使用膳食补充剂的主要人群是运动员，从业余运动员到精英运动员都有。除了与使用膳食补充剂相关的潜在健康风险外，运动员还应注意不要违反世界反兴奋剂机构的规定，因为运动员仍应对其生物液中检测到的物质负责，无论其来源如何。已经开发了几种分析方法来确定作为污染物的兴奋剂的存在。本综述试图解决与营养补充剂的使用以及作为污染物的兴奋剂在膳食补充剂中的检测有关的问题。
