多种凝固酶阴性葡萄球菌菌株诱导的血小板聚集。
Platelet aggregation induced by strains of various species of coagulase-negative staphylococci.
作者信息
Usui Y, Ohshima Y, Ichiman Y, Ohtomo T, Suganuma M, Yoshida K
机构信息
Department of Microbiology, St. Marianna University School of Medicine, Kanagawa.
出版信息
Microbiol Immunol. 1991;35(1):15-26. doi: 10.1111/j.1348-0421.1991.tb01529.x.
Major species of coagulase-negative staphylococci (CNS) were tested for their ability to induce platelet aggregation in rabbit platelet-rich plasma (PRP). Among 11 species of CNS tested, a majority of the strains of 10 species of CNS (S. epidermidis, S. simulans, S. capitis, S. hyicus, S. sciuri, S. cohnii, S. xylosus, S. hominis, S. haemolyticus, S. warneri) caused induction of the platelet aggregation and serotonin release, while S. saprophyticus did not show such activity. The addition of aspirin (10 mM) or quinacrine (1 mM) to PRP resulted in no remarkable effect on the platelet aggregation induced by these strains and it was shown that the platelet aggregation did not require arachidonate pathways. Complement system components were shown to be one of the plasma factors required for platelet aggregation by ten strains of each species of CNS. The bacterial substance participating in the platelet aggregation by ten species of CNS tested was indicated to be heat-stable and trypsin-resistant, while the activity of a strain of S. epidermidis was susceptible to trypsin.
对凝固酶阴性葡萄球菌（CNS）的主要菌种进行了检测，以评估它们在兔富血小板血浆（PRP）中诱导血小板聚集的能力。在所检测的11种CNS中，10种CNS（表皮葡萄球菌、模仿葡萄球菌、头葡萄球菌、猪葡萄球菌、松鼠葡萄球菌、科氏葡萄球菌、木糖葡萄球菌、人葡萄球菌、溶血葡萄球菌、沃氏葡萄球菌）的大多数菌株可诱导血小板聚集和5-羟色胺释放，而腐生葡萄球菌则无此活性。向PRP中添加阿司匹林（10 mM）或奎纳克林（1 mM）对这些菌株诱导的血小板聚集无显著影响，并且表明血小板聚集不需要花生四烯酸途径。补体系统成分被证明是每种CNS的10个菌株诱导血小板聚集所需的血浆因子之一。参与所检测的10种CNS诱导血小板聚集的细菌物质被证明是热稳定且抗胰蛋白酶的，而一株表皮葡萄球菌的活性对胰蛋白酶敏感。
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