[Familiar gastric cancer: case report and systematic review of the Chinese literature].

OBJECTIVE

To investigate the clinicopathologic characteristics of familiar gastric cancer (FGC) in Chinese.

METHODS

A family with FGC was screened. China National Knowledge Infrastructure was retrieved, and fifteen families with FGC were collected. Systematic literature review was carried out on these sixteen families.

RESULTS

There were 63 cases of FGC in these 16 families, 38 males and 25 females, aged 54 (30 - 72). The mean age of the parental patients was 61, older than that of the filial patients (43 years, Z = 3.494, P < 0.01). There was a correlation between the ages of sibling patients (r(s) = 0.664, P < 0.01). Among the 44 cases with clearly described tumor location, the tumor was located in the gastric antrum in 21 patients (47.7%). Among the 8 families with complete records of tumor location, 4 families showed consistent tumor location. Accompanying other malignant tumors were seen in 7 families, 5 being tumors in the alimentary canal.

CONCLUSION

The onset age of filial patients with FGC is younger than that of the parental patients in Chinese. The onset ages of the sibling cases are significantly correlated. In a specific family the tumor is nearly located at the same places. And most of tumors are located in gastric antrum.Most of the accompanying tumors are alimentary canal tumors.