Department of Gastrointestinal Surgery, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University, 67, West Dongchang Road, Liaocheng, Shandong, 252000, China.
Fam Cancer. 2011 Sep;10(3):573-9. doi: 10.1007/s10689-011-9452-z.
An understanding of the clinical features of gastric cancer (GC) in hereditary diffuse gastric cancer (HDGC) families may be helpful in deciding who should receive prophylactic total gastrectomy and when. This study evaluates the sex ratio and age of onset features of these patients. Forty-seven HDGC families were screened from the English (40 families), Chinese (7 families) literature. One family was ascertained in our hospital. A total of 48 HDGC families with 192 GC cases were analyzed. The patients were grouped as Asian and non-Asian cases according the first author corresponding address. The male to female ratio of GC patients in our study was less than general GC population (0.769 vs. 1.826, P < 0.0001). The mean age of male cases was higher than that for females (48.9 vs. 43.1 years; P = 0.012). The mean age for parents of cases was higher than that for the offspring of cases (52.5 vs. 37.4 years; P = 0.0001). There was a significant age correlation between sib-sib GC pairs (P < 0.0001). The male to female ratio of Asian GC patients was higher than that of non-Asian GC cases (1.450 vs. 0.614, P = 0.01). The age for Asian GC patients was higher than that of non-Asian GC patients (52.1 vs. 43.5 years, P = 0.001). The results showed that female GC patients were more frequent and younger than male patients in HDGC families. The parents of cases were older than offspring cases. There was a significant age correlation between sib-sib cases. There was regional disparity in the sex ratio and age features.
了解遗传性弥漫性胃癌 (HDGC) 家族中胃癌 (GC) 的临床特征，可能有助于确定哪些人应接受预防性全胃切除术以及何时进行。本研究评估了这些患者的性别比例和发病年龄特征。从英文（40 个家庭）和中文（7 个家庭）文献中筛选出 47 个 HDGC 家族，并在我院确定了 1 个家族。共分析了 48 个 HDGC 家族的 192 例 GC 病例。根据第一作者的对应地址，将患者分为亚洲和非亚洲病例。本研究中 GC 患者的男女比例低于一般 GC 人群（0.769 比 1.826，P < 0.0001）。男性病例的平均年龄高于女性病例（48.9 岁比 43.1 岁；P = 0.012）。病例父母的平均年龄高于病例子女的平均年龄（52.5 岁比 37.4 岁；P = 0.0001）。同胞 GC 对之间存在显著的年龄相关性（P < 0.0001）。亚洲 GC 患者的男女比例高于非亚洲 GC 病例（1.450 比 0.614，P = 0.01）。亚洲 GC 患者的年龄高于非亚洲 GC 患者（52.1 岁比 43.5 岁，P = 0.001）。结果表明，HDGC 家族中女性 GC 患者比男性患者更常见且更年轻。病例的父母比病例的子女年龄更大。同胞病例之间存在显著的年龄相关性。性别比例和年龄特征存在地域差异。
