Moustakas Aristidis
Ludwig Institute for Cancer Research, Uppsala University, Box 595 Biomedical Center, Uppsala, Sweden.
Dev Cell. 2008 Dec;15(6):797-9. doi: 10.1016/j.devcel.2008.11.009.
In the absence of UV radiation, keratinocytes secrete TGF-beta which blocks melanocyte differentiation. Yang et al. (2008), in a recent issue of Molecular Cell, show that TGF-beta induces Smad signaling in melanocytes to repress PAX3, which encodes a transcription factor crucial for melanocyte differentiation. In the presence of UV radiation, a Jnk/AP-1 pathway represses TGF-beta, which together with a UV-induced p53 pathway promotes melanocyte differentiation.
在没有紫外线辐射的情况下，角质形成细胞分泌转化生长因子-β（TGF-β），它会阻断黑素细胞的分化。Yang等人（2008年）在最近一期的《分子细胞》杂志上表明，TGF-β在黑素细胞中诱导Smad信号传导，以抑制PAX3，PAX3编码一种对黑素细胞分化至关重要的转录因子。在有紫外线辐射的情况下，Jnk/AP-1信号通路会抑制TGF-β，TGF-β与紫外线诱导的p53信号通路共同促进黑素细胞的分化。
