[中非共和国第2健康区的痉挛性截瘫疾病暴发]
[Outbreak of konzo disease in health region No. 2 of the Central African Republic].
作者信息
Mbelesso P, Yogo M-L, Yangatimbi E, Paul-Sénékian V de, Nali N M, Preux P-M
机构信息
Service de neurologie, hôpital de l'Amitié, Bangui, République centrafricaine.
出版信息
Rev Neurol (Paris). 2009 May;165(5):466-70. doi: 10.1016/j.neurol.2008.10.020. Epub 2008 Dec 10.
INTRODUCTION
Konzo is a neuromyelopathy characterized by permanent spastic paraparesis, linked to a subacute poisoning by cyanide found in cassava. The purpose of the study is to describe the epidemiological aspects of konzo in health region No. 2 in the Central African Republic.
METHOD
A descriptive cross-sectional study was conducted among patients collected during a one-month period (July 16 to August 16, 2007) of active surveillance for acute flaccid paralysis.
RESULTS
Eighty-one cases of konzo were identified during the study period, representing a prevalence of 10 per 100,000. Mean age of patients was 10.7+/-7.7 years. Children and women were most affected. The main warning signs were fatigability (97.6%), tremor (88.9%), walking difficulty (100.0%), dysarthria (67.9%) and a loss of visual acuity (65.4%). The predominant neurological signs were lower limb paresis (90.0%) and hyperesthesia (66.7%).
CONCLUSION
Konzo is a serious public health problem in this region of the Central African Republic. A prevention program should be set-up.
引言
konzo是一种以永久性痉挛性截瘫为特征的神经脊髓病，与木薯中发现的氰化物亚急性中毒有关。本研究的目的是描述中非共和国第2健康区konzo的流行病学特征。
方法
在2007年7月16日至8月16日为期一个月的急性弛缓性麻痹主动监测期间收集的患者中进行了一项描述性横断面研究。
结果
研究期间共确诊81例konzo病例，患病率为十万分之十。患者的平均年龄为10.7±7.7岁。儿童和妇女受影响最大。主要警示症状为疲劳（97.6%）、震颤（88.9%）、行走困难（100.0%）、构音障碍（67.9%）和视力丧失（65.4%）。主要神经系统体征为下肢轻瘫（90.0%）和感觉过敏（66.7%）。
结论
konzo在中非共和国的这一地区是一个严重的公共卫生问题。应制定预防计划。
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