Leri Annarosa, Hosoda Toru, Rota Marcello, Kajstura Jan, Anversa Piero
Departments of Anesthesia and Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Drug Discov Today Dis Mech. 2007;4(3):197-203. doi: 10.1016/j.ddmec.2008.02.008.
A problem in need of resolution concerns the origin of cardiac progenitor cells and the mechanisms by which these cells are preserved within the cardiac niches. This may be accomplished by migration of progenitor cells from the bone marrow to the myocardium. Alternatively, the progenitor cell compartment in the heart may be maintained by asymmetric division of resident cells. These two possibilities are not mutually exclusive and both exogenous and endogenous progenitor cells may contribute to cardiac homeostasis.
一个亟待解决的问题涉及心脏祖细胞的起源以及这些细胞在心脏生态位中得以保存的机制。这可能通过祖细胞从骨髓迁移至心肌来实现。或者，心脏中的祖细胞区室可能通过驻留细胞的不对称分裂得以维持。这两种可能性并非相互排斥，外源性和内源性祖细胞都可能有助于心脏内环境稳定。
