小分子的可控折叠调节DNA G-四链体识别。
Controlled-folding of a small molecule modulates DNA G-quadruplex recognition.
作者信息
Müller Sebastian, Pantoş G Dan, Rodriguez Raphaël, Balasubramanian Shankar
机构信息
The University Chemical Laboratory, University of Cambridge, Cambridge, CB2 1EW, UK.
出版信息
Chem Commun (Camb). 2009 Jan 7(1):80-2. doi: 10.1039/b816861j. Epub 2008 Nov 12.
Abstract
Differential recognition of diverse G-quadruplex structures can be achieved by controlling the folding of a small molecule.
摘要
通过控制小分子的折叠，可以实现对多种G-四链体结构的差异识别。
相似文献
1
Controlled-folding of a small molecule modulates DNA G-quadruplex recognition.小分子的可控折叠调节DNA G-四链体识别。
Chem Commun (Camb). 2009 Jan 7(1):80-2. doi: 10.1039/b816861j. Epub 2008 Nov 12.
2
Quadruplex formation by a guanine-rich PNA oligomer.富含鸟嘌呤的肽核酸（PNA）寡聚物形成四链体结构。
J Am Chem Soc. 2005 Mar 30;127(12):4199-207. doi: 10.1021/ja0446202.
3
Ion-selective formation of a guanine quadruplex on DNA origami structures.在 DNA 折纸结构上选择性形成鸟嘌呤四链体。
Angew Chem Int Ed Engl. 2015 Jan 7;54(2):673-7. doi: 10.1002/anie.201409278. Epub 2014 Nov 20.
4
Specific recognition of human telomeric G-quadruplex DNA with small molecules and the conformational analysis by ESI mass spectrometry and circular dichroism spectropolarimetry.小分子对人端粒G-四链体DNA的特异性识别以及通过电喷雾电离质谱和圆二色光谱偏振法进行的构象分析。
Chemistry. 2007;13(17):5018-23. doi: 10.1002/chem.200601605.
5
Fluorescence resonance energy transfer in the studies of guanine quadruplexes.鸟嘌呤四链体研究中的荧光共振能量转移
Methods Mol Biol. 2006;335:311-41. doi: 10.1385/1-59745-069-3:311.
6
Engineering the quadruplex fold: nucleoside conformation determines both folding topology and molecularity in guanine quadruplexes.构建四链体折叠结构：核苷构象决定鸟嘌呤四链体的折叠拓扑结构和分子性。
J Am Chem Soc. 2006 May 3;128(17):5966-73. doi: 10.1021/ja0603958.
7
Mass spectrometry of G-quadruplex DNA: formation, recognition, property, conversion, and conformation.四链体 DNA 的质谱分析：形成、识别、性质、转化和构象。
Mass Spectrom Rev. 2011 Nov-Dec;30(6):1121-42. doi: 10.1002/mas.20315. Epub 2011 Apr 22.
8
Quadruplex structures in nucleic acids.核酸中的四重结构。
Biopolymers. 2000;56(3):123-46. doi: 10.1002/1097-0282(2000/2001)56:3<123::AID-BIP10010>3.0.CO;2-3.
9
Direct measurement of sequential folding pathway and energy landscape of human telomeric G-quadruplex structures.直接测量人类端粒 G-四链体结构的顺序折叠途径和能量景观。
J Am Chem Soc. 2013 May 1;135(17):6423-6. doi: 10.1021/ja4019176. Epub 2013 Apr 23.
10
Determining the folding and unfolding rate constants of nucleic acids by biosensor. Application to telomere G-quadruplex.利用生物传感器测定核酸的折叠和解折叠速率常数。应用于端粒G-四链体。
J Am Chem Soc. 2004 Oct 20;126(41):13255-64. doi: 10.1021/ja048398c.
引用本文的文献
1
Acrylonitrile-Mediated Nascent RNA Sequencing for Transcriptome-Wide Profiling of Cellular RNA Dynamics.用于细胞RNA动态全转录组分析的丙烯腈介导的新生RNA测序
Adv Sci (Weinh). 2020 Mar 5;7(8):1900997. doi: 10.1002/advs.201900997. eCollection 2020 Apr.
2
Importance of Chiral Recognition in Designing Metal-Free Ligands for G-Quadruplex DNA.手性识别在设计用于 G-四链体 DNA 的无金属配体中的重要性。
Molecules. 2019 Apr 15;24(8):1473. doi: 10.3390/molecules24081473.
3
Targeting DNA G-quadruplexes with helical small molecules.用螺旋小分子靶向DNA G-四链体。
Chembiochem. 2014 Nov 24;15(17):2563-70. doi: 10.1002/cbic.201402439. Epub 2014 Sep 26.
4
Targeting the c-Kit Promoter G-quadruplexes with 6-Substituted Indenoisoquinolines.用6-取代茚并异喹啉靶向c-Kit启动子G-四链体
ACS Med Chem Lett. 2010 Jul 1;1(7):306-10. doi: 10.1021/ml100062z. eCollection 2010 Oct 14.
5
Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells.吡啶硫酮类似物促进人类癌细胞中端粒功能障碍和长期生长抑制。
Org Biomol Chem. 2012 Aug 28;10(32):6537-46. doi: 10.1039/c2ob25830g. Epub 2012 Jul 13.
6
Use of a designed Peptide library to screen for binders to a particular DNA g-quadruplex sequence.使用设计的肽库筛选与特定DNA G-四链体序列结合的分子。
J Nucleic Acids. 2011;2011:572873. doi: 10.4061/2011/572873. Epub 2011 Sep 6.
7
G-quadruplex structures and G-quadruplex-interactive compounds.G-四链体结构与G-四链体相互作用化合物
Methods Mol Biol. 2011;735:77-96. doi: 10.1007/978-1-61779-092-8_8.
8
Small-molecule-mediated G-quadruplex isolation from human cells.小分子介导的人细胞中 G-四链体的分离。
Nat Chem. 2010 Dec;2(12):1095-8. doi: 10.1038/nchem.842. Epub 2010 Oct 10.
本文引用的文献
1
A novel small molecule that alters shelterin integrity and triggers a DNA-damage response at telomeres.一种新型小分子，可改变端粒保护蛋白复合体的完整性并在端粒处引发DNA损伤反应。
J Am Chem Soc. 2008 Nov 26;130(47):15758-9. doi: 10.1021/ja805615w.
2
Exploring the differential recognition of DNA G-quadruplex targets by small molecules using dynamic combinatorial chemistry.利用动态组合化学探索小分子对DNA G-四链体靶点的差异识别
Angew Chem Int Ed Engl. 2008;47(14):2677-80. doi: 10.1002/anie.200705589.
3
A hitchhiker's guide to G-quadruplex ligands.G-四链体配体的指南
Org Biomol Chem. 2008 Feb 21;6(4):627-36. doi: 10.1039/b714772b. Epub 2007 Nov 14.
4
Amide bond direction modulates G-quadruplex recognition and telomerase inhibition by 2,6 and 2,7 bis-substituted anthracenedione derivatives.酰胺键方向通过2,6和2,7双取代蒽二酮衍生物调节G-四链体识别和端粒酶抑制作用。
Bioorg Med Chem. 2008 Jan 1;16(1):354-61. doi: 10.1016/j.bmc.2007.09.040. Epub 2007 Sep 25.
5
Trisubstituted isoalloxazines as a new class of G-quadruplex binding ligands: small molecule regulation of c-kit oncogene expression.三取代异咯嗪作为一类新型的G-四链体结合配体：c-kit癌基因表达的小分子调控
J Am Chem Soc. 2007 Oct 31;129(43):12926-7. doi: 10.1021/ja075881p. Epub 2007 Oct 5.
6
Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands.大环和螺旋状低聚酰胺作为一类新型的G-四链体配体。
J Am Chem Soc. 2007 Oct 3;129(39):11890-1. doi: 10.1021/ja073775h. Epub 2007 Sep 11.
7
Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc by quindoline derivatives.喹啉衍生物对G-四链体DNA的稳定作用及癌基因c-myc的下调
J Med Chem. 2007 Apr 5;50(7):1465-74. doi: 10.1021/jm0610088. Epub 2007 Mar 9.
8
Structural basis for binding of porphyrin to human telomeres.卟啉与人类端粒结合的结构基础。
Biochemistry. 2007 Mar 6;46(9):2390-7. doi: 10.1021/bi062244n. Epub 2007 Feb 3.
9
Oxazole-based peptide macrocycles: a new class of G-quadruplex binding ligands.基于恶唑的肽大环化合物：一类新型的G-四链体结合配体。
J Am Chem Soc. 2006 Oct 25;128(42):13662-3. doi: 10.1021/ja064713e.
10
The G-quadruplex ligand telomestatin inhibits POT1 binding to telomeric sequences in vitro and induces GFP-POT1 dissociation from telomeres in human cells.G-四链体配体端粒抑素在体外抑制POT1与端粒序列的结合，并诱导人细胞中绿色荧光蛋白标记的POT1从端粒上解离。
Cancer Res. 2006 Jul 15;66(14):6908-12. doi: 10.1158/0008-5472.CAN-06-1581.
Zotero 插件