通过动态动力学拆分，使用均相手性镍-双膦配合物对α-氨基-β-酮酯盐酸盐进行催化不对称氢化。
Catalytic asymmetric hydrogenation of alpha-amino-beta-keto ester hydrochlorides using homogeneous chiral nickel-bisphosphine complexes through DKR.
作者信息
Hamada Yasumasa, Koseki Yu, Fujii Takefumi, Maeda Tsukuru, Hibino Takuya, Makino Kazuishi
机构信息
Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho, Inage-ku, Chiba, 263-8522, Japan.
出版信息
Chem Commun (Camb). 2008 Dec 14(46):6206-8. doi: 10.1039/b816524f. Epub 2008 Oct 31.
DOI:10.1039/b816524f
PMID:19082121
Abstract
Homogeneous chiral nickel-bisphosphine complexes catalyze the asymmetric hydrogenation of alpha-amino-beta-keto ester hydrochlorides through dynamic kinetic resolution to efficiently afford anti-beta-hydroxy-alpha-amino esters with high diastereo- and enantioselectivities.
摘要
均相手性镍-双膦配合物通过动态动力学拆分催化α-氨基-β-酮酯盐酸盐的不对称氢化反应，从而高效地得到具有高非对映选择性和对映选择性的反式-β-羟基-α-氨基酯。
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