无铜“点击”反应：叠氮化物与芳炔的1,3-偶极环加成反应
Copper-free 'click': 1,3-dipolar cycloaddition of azides and arynes.
作者信息
Campbell-Verduyn Lachlan, Elsinga Philip H, Mirfeizi Leila, Dierckx Rudi A, Feringa Ben L
机构信息
Stratingh Institute for Chemistry, University of Groningen, Groningen, The Netherlands.
出版信息
Org Biomol Chem. 2008 Oct 7;6(19):3461-3. doi: 10.1039/b812403e. Epub 2008 Aug 13.
DOI:10.1039/b812403e
PMID:19082144
Abstract
Arynes formed through fluoride-promoted ortho-elimination of o-(trimethylsilyl)aryl triflates can undergo [3 + 2] cycloaddition with various azides to form substituted benzotriazoles. The rapid reaction times and mild conditions make this an attractive variation of the classical 'click' reaction of azides and alkynes.
摘要
通过氟化物促进邻位（三甲基硅基）芳基三氟甲磺酸酯的邻位消除形成的芳炔可以与各种叠氮化物发生[3 + 2]环加成反应，生成取代的苯并三唑。快速的反应时间和温和的条件使其成为叠氮化物与炔烃经典“点击”反应的一种有吸引力的变体。
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