人类碳酸酐酶I基因有两个具有不同组织特异性的启动子。
The human carbonic anhydrase I gene has two promoters with different tissue specificities.
作者信息
Brady H J, Lowe N, Sowden J C, Edwards M, Butterworth P H
机构信息
Department of Biochemistry, University College London, U.K.
出版信息
Biochem J. 1991 Aug 1;277 ( Pt 3)(Pt 3):903-5. doi: 10.1042/bj2770903.
Primer extension and S1 nuclease analysis of human carbonic anhydrase I (HCA1) mRNA transcripts in erythroid and non-erythroid tissues show that the HCA1 gene has two promoters with different tissue specificities, separated by 36 kb of DNA. The promoter of the HCA1 gene which is active in non-erythroid tissue shows strong sequence similarity with a similar region in the mouse CA1 gene, but has two equally used transcription start sites.
对人类碳酸酐酶I（HCA1）在红细胞和非红细胞组织中的mRNA转录本进行引物延伸和S1核酸酶分析表明，HCA1基因有两个具有不同组织特异性的启动子，它们被36 kb的DNA隔开。在非红细胞组织中活跃的HCA1基因启动子与小鼠CA1基因的类似区域有很强的序列相似性，但有两个同等使用的转录起始位点。
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