Pedrosa Michele Lopes, Mattos Inês Echenique, Koifman Rosalina Jorge
Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz, Rio de Janeiro, Brasil.
Cad Saude Publica. 2008 Dec;24(12):2881-90. doi: 10.1590/s0102-311x2008001200017.
The prevalence of cervical intraepithelial neoplasias has increased in adolescents, probably due to the decrease in age at first intercourse and increase in the number of sexual partners. Our objective was to analyze the trends in cervical intraepithelial lesions in adolescents in the city of Rio de Janeiro, Brazil. We thus conducted a retrospective analysis of 1,516,407 Pap smears performed at public health units from 1999 to 2005. During the study period, the distribution and temporal trend in cytological abnormalities was compared between adolescent and adult women. There were more atypical smears in adolescents, mainly low-grade lesions. In adolescents, cervical abnormalities doubled during this period, from 6.4% to 12.4%, while in adult women it increased from 4.5% to 6.7%. Statistical analysis showed a tendency towards a linear increase in frequency of abnormal Pap smears in both adolescents and adults (0.008% and 0.003%, respectively). Based on this and other studies, we recommend including adolescents in the target population of the Brazilian cervical cancer screening program ("Programa Viva Mulher").
青少年宫颈上皮内瘤变的患病率有所上升，这可能是由于首次性交年龄降低以及性伴侣数量增加所致。我们的目的是分析巴西里约热内卢市青少年宫颈上皮内病变的趋势。因此，我们对1999年至2005年在公共卫生单位进行的1,516,407次巴氏涂片进行了回顾性分析。在研究期间，比较了青少年女性和成年女性细胞学异常的分布及时间趋势。青少年中不典型涂片更多，主要是低级别病变。在此期间，青少年宫颈异常情况翻倍，从6.4%增至12.4%，而成年女性则从4.5%增至6.7%。统计分析表明，青少年和成年女性巴氏涂片异常频率均呈线性增加趋势（分别为0.008%和0.003%）。基于此项研究及其他研究，我们建议将青少年纳入巴西宫颈癌筛查项目（“活力女性项目”）的目标人群。
