环磷酸腺苷对大鼠面神经再生的影响。
Influence of cyclic AMP on facial nerve regeneration in rats.
作者信息
Borin Andrei, Toledo Ronaldo Nunes, Ho Paulo Lee, Testa José Ricardo Gurgel, Cruz Oswaldo Laércio Mendonça, Fukuda Yotaka
机构信息
Master's degree in otorhinolaryngology; doctoral student.
Biologist and doctorate in biochemistry; researcher at the Centro de Biotecnologia, Instituto Butantan.
出版信息
Braz J Otorhinolaryngol. 2008 Sep-Oct;74(5):675-683. doi: 10.1016/S1808-8694(15)31376-8.
UNLABELLED
Promoting facial nerve regeneration is a significant challenge.
AIM
To evaluate the possible neurotrophic influence of cyclic AMP on facial nerve regeneration of Wistar rats.
METHOD
The right facial nerve of thirty-two animals were completely transected and immediately sutured, followed by exposure or not to topical cyclic AMP. Behavioral and histometric analyses were done at 14 and 28 days.
RESULTS
Statistical differences (p<0.05) were found in the behavioral and histometric analyses on the 14th day, suggesting an early regenerative response of the facial nerve to cAMP exposure.
CONCLUSION
This study demonstrates a possible neurotrophic effect of cAMP on facial nerve regeneration in rats.
未标记
促进面神经再生是一项重大挑战。
目的
评估环磷酸腺苷（cAMP）对Wistar大鼠面神经再生可能的神经营养作用。
方法
将32只动物的右侧面神经完全横断并立即缝合，随后给予或不给予局部环磷酸腺苷。在第14天和第28天进行行为学和组织学分析。
结果
在第14天的行为学和组织学分析中发现了统计学差异（p<0.05），提示面神经对环磷酸腺苷暴露有早期再生反应。
结论
本研究证明了环磷酸腺苷对大鼠面神经再生可能具有神经营养作用。
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