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在肌肉骨骼再生工程中利用环磷酸腺苷(cAMP)信号传导

Harnessing cAMP signaling in musculoskeletal regenerative engineering.

作者信息

Ifegwu Okechukwu Clinton, Awale Guleid, Rajpura Komal, Lo Kevin W-H, Laurencin Cato T

机构信息

Institute for Regenerative Engineering, University of Connecticut Health Center, School of Medicine, Farmington, CT 06030, USA; The Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, University of Connecticut Health Center, School of Medicine, Farmington, CT 06030, USA; Department of Orthopedic Surgery, University of Connecticut Health Center, Farmington, CT 06030, USA.

Institute for Regenerative Engineering, University of Connecticut Health Center, School of Medicine, Farmington, CT 06030, USA; The Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, University of Connecticut Health Center, School of Medicine, Farmington, CT 06030, USA; Department of Chemical and Biomolecular Engineering, University of Connecticut, School of Engineering, Storrs, CT 06030, USA.

出版信息

Drug Discov Today. 2017 Jul;22(7):1027-1044. doi: 10.1016/j.drudis.2017.03.008. Epub 2017 Mar 27.

DOI:10.1016/j.drudis.2017.03.008
PMID:28359841
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7440772/
Abstract

This paper reviews the most recent findings in the search for small molecule cyclic AMP analogues regarding their potential use in musculoskeletal regenerative engineering.

摘要

本文综述了在寻找小分子环磷酸腺苷类似物用于肌肉骨骼再生工程方面的最新研究成果。

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本文引用的文献

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Engineered Bone Tissue with Naturally-Derived Small Molecules.具有天然衍生小分子的工程化骨组织。
Curr Pharm Des. 2017;23(24):3585-3594. doi: 10.2174/1381612823666170516145800.
2
Positional information in axolotl and mouse limb extracellular matrix is mediated via heparan sulfate and fibroblast growth factor during limb regeneration in the axolotl (Ambystoma mexicanum).在美西螈(墨西哥钝口螈)肢体再生过程中,美西螈和小鼠肢体细胞外基质中的位置信息是通过硫酸乙酰肝素和成纤维细胞生长因子介导的。
Regeneration (Oxf). 2015 Oct 12;2(4):182-201. doi: 10.1002/reg2.40. eCollection 2015 Aug.
3
Second Messengers.第二信使
Cold Spring Harb Perspect Biol. 2016 Aug 1;8(8):a005926. doi: 10.1101/cshperspect.a005926.
4
Physical and Chemical Signals That Promote Vascularization of Capillary-Scale Channels.促进毛细血管尺度通道血管生成的物理和化学信号。
Cell Mol Bioeng. 2016 Mar 1;9(1):73-84. doi: 10.1007/s12195-016-0429-8. Epub 2016 Jan 19.
5
The Quest toward limb regeneration: a regenerative engineering approach.追求肢体再生:一种再生工程方法。
Regen Biomater. 2016 Jun;3(2):123-5. doi: 10.1093/rb/rbw002. Epub 2016 Mar 5.
6
Mechanisms of cyclic AMP/protein kinase A- and glucocorticoid-mediated apoptosis using S49 lymphoma cells as a model system.以S49淋巴瘤细胞为模型系统,研究环磷酸腺苷/蛋白激酶A和糖皮质激素介导的细胞凋亡机制。
Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12681-6. doi: 10.1073/pnas.1516057112. Epub 2015 Sep 28.
7
Targeted delivery as key for the success of small osteoinductive molecules.靶向递送是小型成骨诱导分子成功的关键。
Adv Drug Deliv Rev. 2015 Nov 1;94:13-27. doi: 10.1016/j.addr.2015.04.022. Epub 2015 May 7.
8
Sphingolipids in liver injury, repair and regeneration.鞘脂类在肝损伤、修复及再生中的作用
Biol Chem. 2015 Jun;396(6-7):633-43. doi: 10.1515/hsz-2014-0296.
9
Cyclic AMP signaling: a molecular determinant of peripheral nerve regeneration.环磷酸腺苷信号传导:周围神经再生的分子决定因素。
Biomed Res Int. 2014;2014:651625. doi: 10.1155/2014/651625. Epub 2014 Aug 7.
10
3D bioprinting of tissues and organs.组织和器官的三维生物打印。
Nat Biotechnol. 2014 Aug;32(8):773-85. doi: 10.1038/nbt.2958.