Scarabino T, Popolizio T, Trojsi F, Giannatempo G, Pollice S, Maggialetti N, Carriero A, Di Costanzo A, Tedeschi G, Salvolini U
U.O. di Neuroradiologia, AUSL BAT, Ospedale Lorenzo Bonomo, Andria, Italy.
Radiol Med. 2009 Apr;114(3):448-60. doi: 10.1007/s11547-008-0351-9. Epub 2008 Dec 11.
The objective of this study was to evaluate the potential role of newly developed, advanced magnetic resonance (MR) imaging techniques (spectroscopy, diffusion and perfusion imaging) in diagnosing brain gliomas, with special reference to histological typing and grading, treatment planning and posttreatment follow-up. Conventional MR imaging enables the detection and localisation of neoplastic lesions, as well as providing, in typical cases, some indication about their nature. However, it has limited sensitivity and specificity in evaluating histological type and grade, delineating margins and differentiating oedema, tumour and treatment side-effects. These limitations can be overcome by supplementing the morphological data obtained with conventional MR imaging with the metabolic, structural and perfusional information provided by new MR techniques that are increasingly becoming an integral part of routine MR studies. Incorporation of such new MR techniques can lead to more comprehensive and precise diagnoses that can better assist surgeons in determining prognosis and planning treatment strategies. In addition, the recent development of new, more effective, treatments for cerebral glioma strongly relies on morphofunctional MR imaging with its ability to provide a biological interpretation of these characteristically heterogeneous tumours.
本研究的目的是评估新开发的先进磁共振（MR）成像技术（光谱学、扩散和灌注成像）在诊断脑胶质瘤方面的潜在作用，特别是在组织学分型和分级、治疗计划及治疗后随访方面。传统MR成像能够检测和定位肿瘤性病变，并且在典型病例中，还能提供一些有关其性质的线索。然而，它在评估组织学类型和分级、勾勒边缘以及区分水肿、肿瘤和治疗副作用方面，敏感性和特异性有限。通过用新MR技术提供的代谢、结构和灌注信息补充常规MR成像获得的形态学数据，可以克服这些局限性，而新MR技术正日益成为常规MR研究不可或缺的一部分。纳入此类新MR技术可导致更全面、精确的诊断，从而更好地协助外科医生确定预后和规划治疗策略。此外，最近针对脑胶质瘤的更有效新治疗方法的开发，在很大程度上依赖于形态功能MR成像，因为它能够对这些具有典型异质性的肿瘤进行生物学解读。
