Unit of Neuroradiology, Department of Neurosciences, Azienda Ospedaliera di Rilievo Nazionale "Gaetano Rummo", Via dell'Angelo, 1, 82100 Benevento, Italy.
J Neurooncol. 2011 Jul;103(3):713-7. doi: 10.1007/s11060-010-0454-8. Epub 2010 Nov 11.
The aim was to assess the value of unenhanced fluid-attenuated inversion recovery T2-weighted sequences (FLAIR-T2) in the differential diagnosis between solitary high-grade gliomas (HGG) and cerebral metastases (CM) appearing as contrast-enhancing cortico-subcortical lesions of the brain. In 69 patients with a contrast-enhancing cortico-subcortical brain lesion (43 HGG, and 26 CM), unenhanced FLAIR-T2 and gadolinium-enhanced FLAIR T1-weighted (Gd-FLAIR-T1) axial images have been reviewed for the involvement of the cortex adjacent to the contrast-enhancing lesion. In 27 (62.79%) out of 43 HGG, and 3 (11.53%) out of 26 CM, the cortex adjacent to the contrast-enhancing lesion showed high signal intensity on unenhanced FLAIR-T2 without enhancement at Gd-FLAIR-T1. Fischer's exact probability test was P = 0.0003 when applied to HGG versus CM categories, indicating a significant difference. The high signal intensity on unenhanced FLAIR-T2 without gadolinium-enhancement of the cortex adjacent to the enhancing lesion is more frequently associated with HGG than CM.
目的是评估未增强的液体衰减反转恢复 T2 加权序列（FLAIR-T2）在高级别胶质瘤（HGG）与脑转移瘤（CM）出现皮质下增强病变的鉴别诊断中的价值。在 69 例增强皮质下脑病变患者（43 例 HGG 和 26 例 CM）中，回顾了未增强的 FLAIR-T2 和钆增强的 FLAIR T1 加权（Gd-FLAIR-T1）轴位图像，以评估与增强病变相邻的皮质的受累情况。在 43 例 HGG 中有 27 例（62.79%），26 例 CM 中有 3 例（11.53%），增强病变相邻的皮质在未增强的 FLAIR-T2 上显示高信号强度，而在 Gd-FLAIR-T1 上无增强。当应用于 HGG 与 CM 类别时，Fischer 确切概率检验的 P = 0.0003，表明存在显著差异。增强病变相邻皮质的未增强 FLAIR-T2 上的高信号强度而无钆增强，与 HGG 的相关性高于 CM。
