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青蒿琥酯抗肿瘤作用的研究进展

Progress in research on the anti-tumor effect of artesunate.

作者信息

HE Rong-rong, ZHOU Huai-jun

机构信息

Gulou Medical College of Integrative Chinese and Western Medicine, The No.1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing (210029), China.

出版信息

Chin J Integr Med. 2008 Dec;14(4):312-6. doi: 10.1007/s11655-008-0312-0. Epub 2008 Dec 12.

Abstract

It has been found in recent years that Artesunate (Art), a water soluble derivative of arteannuin, mainly previously used for its anti-malarial activity, has some other effects, e.g. it could act as an anti-tumor agent by way of inducing cell apoptosis, antagonizing angiogenesis, reversing immunosuppression of tumor cells, etc. More and more attention is being paid to the anti-tumor effects of Art. Such progress is reviewed in this paper.

摘要

近年来发现,青蒿琥酯(Art)是青蒿素的水溶性衍生物,以前主要因其抗疟活性而被使用,它还有其他一些作用,例如它可以通过诱导细胞凋亡、拮抗血管生成、逆转肿瘤细胞的免疫抑制等方式发挥抗肿瘤作用。青蒿琥酯的抗肿瘤作用越来越受到关注。本文对这方面的进展进行综述。

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