Watson Ronald Ross, Zibadi Sherma, Rafatpanah Houshang, Jabbari Farahzad, Ghasemi Ramin, Ghafari Javad, Afrasiabi Hadi, Foo Lai Yeap, Faridhosseini Reza
Southwest Scientific Editing and Consulting L.L.C., Tucson, AZ 85749, USA.
Nutr Res. 2008 Mar;28(3):166-71. doi: 10.1016/j.nutres.2008.01.003.
Asthma, affecting as many as 400 million individuals worldwide, is one of the most prevalent chronic health condition in the United States. With an increasing number of patients with asthma and the frequent inability of conventional lifestyle modification and therapy to effectively control the problem, nutritional and dietary therapies are being sought. This study was undertaken to investigate the efficacy of the purple passion fruit peel (PFP) extract, a novel mixture of bioflavonoids, on asthma symptoms. Patients with asthma were studied in a 4-week randomized, placebo-controlled, double-blind trial with oral administration of PFP extract (150 mg/d) or placebo pills. The effects of PFP extract were evaluated by assessing the clinical symptoms of asthma and spirometry tests. Most clinical symptoms of asthma of the PFP extract-treated group were moderated significantly compared to the baseline. The prevalence of wheeze, cough, as well as shortness of breath was reduced significantly in group treated with PFP extract (P < .05), whereas the placebo caused no significant improvement. Purple passion fruit peel extract supplementation resulted in a marked increase in forced vital capacity (P < .05) as placebo showed no effect. However, no significant improvement was observed in the forced expiratory volume at 1 second of those supplemented with PFP extract. No adverse effect was reported by any of study participants. The PFP extract may be safely offered to asthmatic subjects as an alternative treatment option to reduce clinical symptoms.
哮喘影响着全球多达4亿人，是美国最普遍的慢性健康问题之一。随着哮喘患者数量的增加，以及传统生活方式改变和治疗常常无法有效控制该问题，人们正在寻求营养和饮食疗法。本研究旨在调查紫色西番莲果皮（PFP）提取物（一种新型生物类黄酮混合物）对哮喘症状的疗效。哮喘患者参加了一项为期4周的随机、安慰剂对照、双盲试验，口服PFP提取物（150毫克/天）或安慰剂药丸。通过评估哮喘的临床症状和肺量计测试来评估PFP提取物的效果。与基线相比，PFP提取物治疗组的大多数哮喘临床症状得到显著缓解。PFP提取物治疗组的喘息、咳嗽以及呼吸急促的发生率显著降低（P < 0.05），而安慰剂组无显著改善。补充紫色西番莲果皮提取物导致用力肺活量显著增加（P < 0.05），而安慰剂组无此效果。然而，补充PFP提取物的受试者在第1秒用力呼气量方面未观察到显著改善。研究参与者均未报告不良反应。PFP提取物可作为一种替代治疗选择安全地提供给哮喘患者，以减轻临床症状。
