Prinz M, Carracedo A, Mayr W R, Morling N, Parsons T J, Sajantila A, Scheithauer R, Schmitter H, Schneider P M
Department of Forensic Biology, Office of Chief Medical Examiner, New York, NY 10016, USA.
Forensic Sci Int Genet. 2007 Mar;1(1):3-12. doi: 10.1016/j.fsigen.2006.10.003. Epub 2006 Nov 28.
The ISFG membership consists of scientists and medical professionals specialized in using genetic testing for kinship analysis and the individualization of biological material. This expertise makes the forensic geneticist a resource of advice to international and national organizations dealing with human identifications and causes many DNA laboratories to get involved in DVI tasks. The present recommendations are meant to educate more forensic geneticists about their potential involvement in mass fatality preparedness and possible DVI efforts, as well as to provide practical guidance for each of the laboratories' individual tasks. The idea to work on DNA-specific recommendations was born after a round table discussion dealing with the 2004 Tsunami disaster in south east Asia during the 21st congress of the International Society for Forensic Genetics on the Azores, Portugal, in September 2005. The ensuing discussion between scientists and pathologists that had been involved in the International Center in Khao Lak, Thailand, revealed the need for the scientific community to be better prepared to answer the local authorities' questions by formulating generally acceptable scientific standards for the most efficient use of DNA-based victim identification methods. These recommendations, as well as the many cited references, are intended to provide guidance on establishing preparedness for the forensic genetics laboratory, on collecting and storing ante-mortem and post-mortem samples suitable for DNA analysis, on DNA extraction and genetic typing strategies, on data management, and on issues related to the biostatistical interpretation and reporting of results.
国际法医遗传学学会（ISFG）的成员包括专门从事利用基因检测进行亲属关系分析和生物样本个体化识别的科学家和医学专业人员。这种专业知识使法医遗传学家成为处理人类身份识别的国际和国家组织的咨询资源，并促使许多DNA实验室参与灾难受害者身份识别（DVI）任务。本建议旨在让更多法医遗传学家了解他们在大规模死亡事件准备工作和可能的DVI工作中的潜在参与情况，并为每个实验室的具体任务提供实际指导。关于制定特定于DNA的建议的想法，源于2005年9月在葡萄牙亚速尔群岛举行的第21届国际法医遗传学大会期间，一次关于2004年东南亚海啸灾难的圆桌讨论。随后，参与泰国攀牙国际中心工作的科学家和病理学家之间的讨论表明，科学界需要做好更充分准备，通过制定普遍认可的科学标准，以便最有效地利用基于DNA的受害者身份识别方法，来回答地方当局的问题。这些建议以及众多引用的参考文献，旨在为法医遗传学实验室的准备工作、适合DNA分析的生前和死后样本的采集与存储、DNA提取和基因分型策略、数据管理以及与结果的生物统计学解释和报告相关的问题提供指导。
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