Capelli Cristian, Brisighelli Francesca, Scarnicci Francesca, Blanco-Verea Alejandro, Brion Maria, Pascali Vince L
Department of Zoology, University of Oxford, Tinbergen Building, South Parks Road, OX1 3PS Oxford, UK.
Forensic Sci Int Genet. 2007 Dec;1(3-4):287-90. doi: 10.1016/j.fsigen.2007.06.001. Epub 2007 Jul 20.
Duplication events at Y chromosome STR loci have been repeatedly described in human populations. DYS19 is probably the best known example and it exhibits duplicate state in individuals from all continents. Despite the large amount of available data, evolutionary relationship between DYS19 duplication-bearing chromosomes has not been so far investigated. We address the genealogical correlation among such chromosomes by analysing newly identified DYS19 duplicated Y chromosomes by SNP genotyping and microsatellite-based network analysis. SNP and network analysis show that DYS19 duplicated Y chromosomes associate with different Y chromosome lineages. These results indicate that DYS19 duplication occurred more than once during human evolution.
Y染色体短串联重复序列（STR）位点的重复事件在人类群体中已被多次描述。DYS19可能是最著名的例子，它在各大洲的个体中都呈现出重复状态。尽管有大量可用数据，但迄今为止尚未研究携带DYS19重复的染色体之间的进化关系。我们通过单核苷酸多态性（SNP）基因分型和基于微卫星的网络分析，分析新鉴定的携带DYS19重复的Y染色体，来探讨此类染色体之间的谱系相关性。SNP和网络分析表明，携带DYS19重复的Y染色体与不同的Y染色体谱系相关。这些结果表明，DYS19重复在人类进化过程中发生了不止一次。
