Markland Alayne D, Richter Holly E, Burgio Kathryn L, Wheeler Thomas L, Redden David T, Goode Patricia S
Division of Gerontology, Geriatrics and Palliative Care, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Am J Obstet Gynecol. 2008 Dec;199(6):699.e1-7. doi: 10.1016/j.ajog.2008.08.035.
To describe how women with fecal incontinence (FI) respond to combined pharmacologic therapy and pelvic floor muscle exercises (PFME).
Validated questionnaires (Fecal Incontinence Severity Index and Modified Manchester Health Questionnaire) were mailed to 80 women who received combined therapy for FI and had complete baseline assessments. Regression models were constructed to identify predictors of change in questionnaire scores.
Response rate was 69%. Mean age was 59 +/- 12 years. All women were taught PFME with digital palpation, and 87% of the women received medications. FI severity scores and quality-of-life (QOL) improved from baseline to follow-up (P < .001 and P = .02, respectively). A fair/normal external anal sphincter (EAS) contraction resulted in greater improvements in FI severity (13 points, P = .006) and QOL scores (22 points, P < .001).
FI severity and QOL improved after combination therapies, and a fair/normal EAS contraction predicted greater improvement.
描述大便失禁（FI）女性对联合药物治疗和盆底肌肉锻炼（PFME）的反应。
向80名接受FI联合治疗且进行了完整基线评估的女性邮寄了经过验证的问卷（大便失禁严重程度指数和改良曼彻斯特健康问卷）。构建回归模型以确定问卷分数变化的预测因素。
回复率为69%。平均年龄为59±12岁。所有女性均通过指诊接受PFME指导，87%的女性接受了药物治疗。从基线到随访，FI严重程度评分和生活质量（QOL）均有所改善（分别为P <.001和P =.02）。肛门外括约肌（EAS）收缩良好/正常导致FI严重程度（13分，P =.006）和QOL评分（22分，P <.001）有更大改善。
联合治疗后FI严重程度和QOL有所改善，EAS收缩良好/正常预示着更大的改善。
