Physiological Psychology, University of Bielefeld, Germany.
Cortex. 2010 Jan;46(1):29-39. doi: 10.1016/j.cortex.2008.07.003. Epub 2008 Nov 7.
Episodic-autobiographical memory (AM) is characterized by self-conscious reflection, emotional connotation and mental time travel. Semantic memory (SM) contains context and emotion free general knowledge. The present study specifically aimed at exploring the effect of time on the neural substrates of autobiographical and semantic memory retrieval by studying memories from different life periods in young female participants using functional brain imaging. Recent compared to early childhood events activated retrosplenial cortex. More importantly, medial prefrontal cortex (MPFC) was specifically engaged in the retrieval of recent AMs. The data show time-modulated neural substrates during recent and remote memories in women and suggest that a specific MPFC activation underlies the autonoetic, emotional and self-related character of recent AMs.
情景自传体记忆（AM）的特点是自我意识反思、情感内涵和心理时间旅行。语义记忆（SM）包含无上下文和情感的一般知识。本研究通过功能性脑成像研究年轻女性参与者不同生命阶段的记忆，专门探讨时间对自传体和语义记忆检索的神经基础的影响。与早期儿童事件相比，最近的事件激活了后扣带回皮质。更重要的是，内侧前额叶皮质（MPFC）专门参与了最近 AM 的检索。这些数据显示了女性近期和远程记忆中时间调节的神经基础，并表明 MPFC 的特定激活是最近 AM 的自主、情感和自我相关特征的基础。
