利用超声技术实现跨血脑屏障的靶向药物递送。
Targeted drug delivery across the blood-brain barrier using ultrasound technique.
作者信息
Deng Cheri X
机构信息
Department of Biomedical Engineering, University of Michigan, 2200 Bonisteel Boulevard, Ann Arbor, MI 48109-2099, USA.
出版信息
Ther Deliv. 2010 Dec;1(6):819-48. doi: 10.4155/tde.10.66.
Abstract
Effective delivery of therapeutic agents into the brain can greatly improve the treatments of neurological and neurodegenerative diseases. Application of focused ultrasound facilitated by microbubbles has shown the potential to deliver drugs across the blood-brain barrier into targeted sites within the brain noninvasively. This review provides a summary of the technological background and principle, highlights of recent significant developments and research progress, as well as a critical commentary on the challenges and future directions in the field. This review also outlines and discusses the tasks that researchers face in order to successfully translate the technology into a clinical reality, including obtaining improved understanding of the mechanisms, demonstration of therapeutic efficacy and safety for specific applications, and development of methodology for rational design to achieve optimized and consistent outcomes.
摘要
将治疗药物有效递送至大脑可极大地改善神经和神经退行性疾病的治疗效果。由微泡辅助的聚焦超声应用已显示出将药物无创地穿过血脑屏障递送至脑内靶向部位的潜力。本综述总结了该技术的背景和原理、近期重大进展和研究成果，以及对该领域挑战和未来方向的批判性评论。本综述还概述并讨论了研究人员为将该技术成功转化为临床实际所面临的任务，包括更好地理解其机制、证明特定应用的治疗效果和安全性，以及开发合理设计方法以实现优化和一致的结果。
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