Ayan Ali Kemal, Cirak Cuneyt
The High School of Profession of Bafra, University of Ondokuz Mayis, Samsun, Turkey.
Nat Prod Res. 2008 Dec;22(18):1597-604. doi: 10.1080/14786410701838213.
The principle medicinal secondary metabolites present in Hypericum species are thought to be naphthodianthrones hypericin and pseudohypericin. The present study was conducted to determine ontogenetic and morphogenetic variations of hypericin and pseudohypericin contents in Hypericum triquetrifolium growing in two sites located in Northern Turkey. Plants were harvested at vegetative, flowering and fructification stages. Plants were dissected into stem, leaf and reproductive tissues at the time of harvest, dried separately and assayed for hypericin and pseudohypericin contents by high-performance liquid chromatography. The hypericin and pseudohypericin concentrations in the leaves and reproductive parts were highest at flowering and fructification, whereas the stem contents of these compounds decreased with advancing plant growth in both sites. The leaves contained higher concentrations of both naphthodianthrones than the stems or reproductive parts of H. triquetrifolium.
金丝桃属植物中主要的药用次生代谢产物被认为是萘并二蒽酮类的金丝桃素和假金丝桃素。本研究旨在确定生长在土耳其北部两个地点的三叶金丝桃中金丝桃素和假金丝桃素含量的个体发育和形态发生变化。在营养期、花期和结果期采集植株。收获时将植株解剖为茎、叶和生殖组织，分别干燥，并通过高效液相色谱法测定金丝桃素和假金丝桃素的含量。在两个地点，叶片和生殖部位中金丝桃素和假金丝桃素的浓度在花期和结果期最高，而这些化合物在茎中的含量随着植株生长而降低。三叶金丝桃的叶片中萘并二蒽酮类化合物的浓度高于茎或生殖部位。
