Zhang Hong-Min, Chen Shi-Wei, Zhang Li-Shi, Feng Xiao-Fan
Henan Eye Institute and Department of Ophthalmology, Henan Provincial People's Hospital, Zhengzhou, PR China.
Nat Prod Res. 2008 Dec;22(18):1637-49. doi: 10.1080/14786410701869598.
The effects of soy isoflavone (SIF) on insulin sensitivity and adipocytokines in high-fat-diet-induced insulin resistant (IR) rats were studied. Male Sprague Dawley rats (n = 80) were randomly assigned into a basal diet fed group and high-fat diet fed group. The high-fat-diet-induced IR rats were assigned into IR model control group and three SIF-treated groups with different dosages. Thirty days later, the fasting blood glucose, insulin and adipocytokines in serum and mRNA expressions of adipocytokines in perirenal white adipose tissue were measured. The Homeostasis Model Assessment of IR was calculated. The administration of 450 mg kg(-1) d(-1) SIF decreased the body weights and depositions of visceral adipose tissue as well as improved insulin resistance in high-fat-diet-induced IR rats. The mechanisms were associated with SIF regulating the expression of adipocytokines, including adiponectin, leptin, resistin and TNF-alpha. SIF supplements may have favourable effects on insulin resistance in high-fat-diet-induced IR rats.
研究了大豆异黄酮（SIF）对高脂饮食诱导的胰岛素抵抗（IR）大鼠胰岛素敏感性和脂肪细胞因子的影响。将雄性Sprague Dawley大鼠（n = 80）随机分为基础饮食喂养组和高脂饮食喂养组。将高脂饮食诱导的IR大鼠分为IR模型对照组和三个不同剂量的SIF治疗组。30天后，测量血清中的空腹血糖、胰岛素和脂肪细胞因子以及肾周白色脂肪组织中脂肪细胞因子的mRNA表达。计算胰岛素抵抗的稳态模型评估值。给予450 mg kg(-1) d(-1)的SIF可降低高脂饮食诱导的IR大鼠的体重和内脏脂肪组织沉积，并改善胰岛素抵抗。其机制与SIF调节脂肪细胞因子的表达有关，包括脂联素、瘦素、抵抗素和肿瘤坏死因子-α。补充SIF可能对高脂饮食诱导的IR大鼠的胰岛素抵抗有有益作用。
