衰老对亲电试剂诱导的还原型谷胱甘肽急性耗竭的影响。

Influence of aging on the acute depletion of reduced glutathione induced by electrophilic agents.

作者信息

Benzi G, Pastoris O, Gorini A, Marzatico F, Villa R F, Curti D

机构信息

Institute of Pharmacology, University of Pavia, Italy.

出版信息

Neurobiol Aging. 1991 May-Jun;12(3):227-31. doi: 10.1016/0197-4580(91)90101-o.

DOI:10.1016/0197-4580(91)90101-o

PMID:1908565

Abstract

A severe age-dependent depletion of reduced glutathione (GSH) occurs in rat forebrain at 1-3 h from intraperitoneal injection of the electrophilic agents cyclohexene-1-one and cycloheptene-1-one. Chronic pretreatment with central dopamine agonists (i.e., ergot alkaloids; particularly, dihydroergocriptine) partially counteracts the GSH depletion induced in 15-month-old forebrains by the prooxidants tested. In contrast, chronic pretreatment with a vasodilator agent (i.e., papaverine) magnifies the GSH depletion.

摘要

从腹膜内注射亲电子试剂环己烯 -1- 酮和环庚烯 -1- 酮起1至3小时内，大鼠前脑会出现严重的、与年龄相关的还原型谷胱甘肽（GSH）耗竭。用中枢多巴胺激动剂（即麦角生物碱；特别是二氢麦角隐亭）进行慢性预处理，可部分抵消受试促氧化剂在15月龄前脑中诱导的GSH耗竭。相反，用血管扩张剂（即罂粟碱）进行慢性预处理会加剧GSH耗竭。