Liu Jun-Feng, Shao Meng, Zhai Da-Wei, Liu Ke, Wu Li-Jun
Planta Med. 2009 Feb;75(2):142-5. doi: 10.1055/s-0028-1088390. Epub 2008 Dec 15.
In the present study, we evaluated the effect of 4-methoxy-5-hydroxycanthin-6-one (CAN), a natural alkaloid isolated from Picrasma quassioides (D.Don) Benn., on ulcerative colitis induced by dextran sulfate sodium (DSS) in rats in comparison with the positive control drug, sulfasalazine (SASP). Given orally for several days, CAN significantly reduced the severity of colitis and mitigated changes in colon length, colon mucosa myeloperoxidase (MPO) activity, and the level of tumor necrosis factor-alpha (TNF-alpha) in serum. The effect of CAN was similar to that of SASP. These results suggest that CAN treatment might be an effective therapeutic intervention against ulcerative colitis induced by DSS.
在本研究中，我们评估了从苦木（Picrasma quassioides (D.Don) Benn.）中分离出的天然生物碱4-甲氧基-5-羟基铁屎米-6-酮（CAN）对葡聚糖硫酸钠（DSS）诱导的大鼠溃疡性结肠炎的影响，并与阳性对照药物柳氮磺胺吡啶（SASP）进行了比较。连续口服数天后，CAN显著降低了结肠炎的严重程度，并减轻了结肠长度、结肠黏膜髓过氧化物酶（MPO）活性以及血清中肿瘤坏死因子-α（TNF-α）水平的变化。CAN的效果与SASP相似。这些结果表明，CAN治疗可能是针对DSS诱导的溃疡性结肠炎的一种有效治疗干预措施。
