米索前列醇对四氯化碳诱导的大鼠肝损伤的保护作用。
Protective effects of misoprostol on carbon tetrachloride-induced liver damage in the rat.
作者信息
Mihas A A, Markov A K, Subramony C
机构信息
Department of Medicine, University of Mississippi Medical Center, Jackson.
出版信息
Pharmacology. 1991;42(5):283-6. doi: 10.1159/000138809.
PMID:1908583
Abstract
Effects of misoprostol on histologic and biochemical alterations caused by CCl4 were investigated in the rat. Misoprostol protected against CCl4-induced liver injury. A close correlation occurred between biochemical data and morphological changes. This hepatoprotective effect was observed only when misoprostol was given 30 min before CCl4.
摘要
在大鼠中研究了米索前列醇对四氯化碳所致组织学和生化改变的影响。米索前列醇可预防四氯化碳诱导的肝损伤。生化数据与形态学变化之间存在密切相关性。仅在四氯化碳给药前30分钟给予米索前列醇时才观察到这种肝保护作用。
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