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Arguable assumptions, debatable conclusions.有争议的假设，有争议的结论。
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[Genetics and stressful life events interact in depression].[遗传学与应激性生活事件在抑郁症中相互作用]
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Polymorphism in the serotonin transporter gene polymorphisms ( 5-HTTLPR) modifies the association between significant life events and depression in people with multiple sclerosis.5-羟色胺转运体基因多态性（5-HTTLPR）多态性改变了多发性硬化症患者重大生活事件与抑郁之间的关联。
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Cholesterol and serotonin transporter polymorphism interactions in late-life depression.胆固醇和 5-羟色胺转运体基因多态性在老年期抑郁症中的相互作用。
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Variability in the effect of 5-HTTLPR on depression in a large European population: the role of age, symptom profile, type and intensity of life stressors.5-羟色胺转运体基因启动子区多态性（5-HTTLPR）对欧洲大量人群抑郁症影响的变异性：年龄、症状特征、生活应激源类型及强度的作用
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Short alleles, bigger smiles? The effect of 5-HTTLPR on positive emotional expressions.短等位基因，更灿烂的笑容？5-羟色胺转运体基因启动子区域多态性（5-HTTLPR）对积极情绪表达的影响。
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The conditioning of intervention effects on early adolescent alcohol use by maternal involvement and dopamine receptor D4 (DRD4) and serotonin transporter linked polymorphic region (5-HTTLPR) genetic variants.母亲参与、多巴胺受体D4（DRD4）和5-羟色胺转运体基因连锁多态性区域（5-HTTLPR）基因变异对青少年早期饮酒干预效果的调节作用。
Dev Psychopathol. 2015 Feb;27(1):51-67. doi: 10.1017/S0954579414001291.
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Genetic determinants of depression: recent findings and future directions.抑郁症的遗传决定因素：最新发现与未来方向。
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The genetics of major depression.重度抑郁症的遗传学。
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No interaction between serotonin transporter gene (5-HTTLPR) polymorphism and adversity on depression among Japanese children and adolescents.在日本儿童和青少年中，5-羟色胺转运体基因（5-HTTLPR）多态性与逆境对抑郁没有相互作用。
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Emerging risk factors for postpartum depression: serotonin transporter genotype and omega-3 fatty acid status.产后抑郁症的新出现风险因素：5-羟色胺转运体基因型和ω-3 脂肪酸状况。
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Candidate and non-candidate genes in behavior genetics.行为遗传学中的候选基因和非候选基因。
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9
Interaction between serotonin transporter polymorphism (5-HTTLPR) and stressful life events in adolescents' trajectories of anxious/depressed symptoms.5-羟色胺转运体基因多态性（5-HTTLPR）与应激性生活事件在青少年焦虑/抑郁症状轨迹中的相互作用。
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10
Stressful life events, perceived stress, and 12-month course of geriatric depression: direct effects and moderation by the 5-HTTLPR and COMT Val158Met polymorphisms.应激性生活事件、感知压力与老年期抑郁症 12 个月病程：5-HTTLPR 和 COMT Val158Met 多态性的直接影响及调节作用
Stress. 2012 Jul;15(4):425-34. doi: 10.3109/10253890.2011.634263. Epub 2012 Jan 4.

本文引用的文献

1
Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis.血清素转运体基因（5-HTTLPR）、应激性生活事件与抑郁症风险之间的相互作用：一项荟萃分析。
JAMA. 2009 Jun 17;301(23):2462-71. doi: 10.1001/jama.2009.878.
2
Early adversity and 5-HTT/BDNF genes: new evidence of gene-environment interactions on depressive symptoms in a general population.早期逆境与5-羟色胺转运体/脑源性神经营养因子基因：普通人群中基因-环境相互作用对抑郁症状影响的新证据。
Psychol Med. 2009 Sep;39(9):1425-32. doi: 10.1017/S0033291709005248. Epub 2009 Feb 12.
3
Psychological vulnerability differences in students--carriers or not of the serotonin transporter promoter allele S: effect of adverse experiences.学生（血清素转运体启动子等位基因S携带者或非携带者）的心理易损性差异：不良经历的影响
Synapse. 2009 Mar;63(3):193-200. doi: 10.1002/syn.20598.
4
Gene X environment interactions at the serotonin transporter locus.血清素转运体基因座处的基因与环境相互作用。
Biol Psychiatry. 2009 Feb 1;65(3):211-9. doi: 10.1016/j.biopsych.2008.06.009. Epub 2008 Aug 8.
5
New evidence for the association of the serotonin transporter gene (SLC6A4) haplotypes, threatening life events, and depressive phenotype.血清素转运体基因（SLC6A4）单倍型、威胁生命事件与抑郁表型之间关联的新证据。
Biol Psychiatry. 2008 Sep 15;64(6):498-504. doi: 10.1016/j.biopsych.2008.03.030. Epub 2008 May 16.
6
The serotonin transporter genotype is associated with intermediate brain phenotypes that depend on the context of eliciting stressor.血清素转运体基因分型与取决于引发应激源背景的中间脑表型相关。
Mol Psychiatry. 2008 Nov;13(11):1021-7. doi: 10.1038/mp.2008.37. Epub 2008 Apr 15.
7
Association between serotonin transporter gene polymorphisms and depressed mood caused by job stress in Japanese workers.
Int J Mol Med. 2008 Apr;21(4):499-505.
8
HPA axis reactivity: a mechanism underlying the associations among 5-HTTLPR, stress, and depression.下丘脑-垂体-肾上腺轴反应性：5-羟色胺转运体基因启动子区多态性、应激与抑郁之间关联的潜在机制
Biol Psychiatry. 2008 May 1;63(9):847-51. doi: 10.1016/j.biopsych.2007.10.008. Epub 2007 Nov 19.
9
Effects of environmental stress and gender on associations among symptoms of depression and the serotonin transporter gene linked polymorphic region (5-HTTLPR).环境压力和性别对抑郁症状与血清素转运体基因连锁多态性区域（5-HTTLPR）之间关联的影响。
Behav Genet. 2008 Jan;38(1):34-43. doi: 10.1007/s10519-007-9172-1. Epub 2007 Oct 23.
10
Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis.血清素转运体（5-HTTLPR）基因型与杏仁核激活：一项荟萃分析。
Biol Psychiatry. 2008 May 1;63(9):852-7. doi: 10.1016/j.biopsych.2007.08.016. Epub 2007 Oct 22.

Arguable assumptions, debatable conclusions.

作者信息

Kaufman Joan, Gelernter Joel, Kaffman Arie, Caspi Avshalom, Moffitt Terrie

出版信息

Biol Psychiatry. 2010 Feb 15;67(4):e19-20; author reply e21-3. doi: 10.1016/j.biopsych.2009.07.041. Epub 2009 Dec 14.

DOI:10.1016/j.biopsych.2009.07.041
PMID:20006323
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3784000/
Abstract
摘要