Klockars Tuomas, Sihvo Eero, Mäkitie Antti
Department of Otorhinolaryngology, Kymenlaakso Central Hospital, Kotka, Finland.
Acta Otolaryngol. 2008 Sep;128(9):1034-6. doi: 10.1080/00016480701813822.
The aetiology of Zenker's diverticulum is likely to be multifactorial. The geographical and racial variation in the prevalence and the rare familial cases suggest that genetic predisposition might have a role in the pathogenesis. The mode of inheritance in the rare possible familial cases seems to be autosomal dominant; recessive inheritance is non-existent or extremely rare.
To study the inheritance of Zenker's diverticulum.
A detailed questionnaire concerning physical health and family history was sent to 122 patients with Zenker's diverticulum.
The prevalence of familial disease in Finland was found to be < 2%. We found no evidence for genetic founder effect.
Zenker憩室的病因可能是多因素的。其患病率的地理和种族差异以及罕见的家族病例表明，遗传易感性可能在发病机制中起作用。在罕见的可能家族性病例中，遗传方式似乎为常染色体显性遗传；隐性遗传不存在或极为罕见。
研究Zenker憩室的遗传情况。
向122例Zenker憩室患者发送了一份关于身体健康和家族史的详细问卷。
芬兰家族性疾病的患病率<2%。我们未发现遗传奠基者效应的证据。
