Miyashita K, Kitamura M, Arai K
Dept. of Surgery, Tokyo Metropolitan Komagome Hospital.
Gan To Kagaku Ryoho. 1991 Aug;18(11):1873-7.
Four patients with hepatic metastasis of gastric cancer (one synchronous, three metachronous), received intraarterial noradrenaline-induced hypertensive chemotherapy. The outlet of the indwelling catheter was placed in the proper hepatic artery in two patients, in the thoracic aorta in one patient and in both places in one patient. When the systolic blood pressure rose 50 percent above the level in the untreated state, mitomycin C via the catheter was administered for 10 minutes. Partial remission was found in 2 patients, NC in one patient and PD in another. One patient showing PR died of a relapse of hepatic metastasis 8 months after treatment. Another patient with PD died of multiple bone metastases after 12 months. The two other patients are alive 19 months after treatment. Intraarterial noradrenaline-induced hypertensive chemotherapy is one of the useful treatments of choice for hepatic metastasis of gastric cancer.
4例胃癌肝转移患者（1例同时性转移，3例异时性转移）接受了动脉内去甲肾上腺素诱导的高血压化疗。2例患者将留置导管的出口置于肝固有动脉，1例置于胸主动脉，1例置于两处。当收缩压比未治疗状态时升高50%时，经导管给予丝裂霉素C 10分钟。2例患者出现部分缓解，1例患者病情稳定，另1例患者病情进展。1例显示部分缓解的患者在治疗后8个月死于肝转移复发。另1例病情进展的患者在12个月后死于多发骨转移。另外2例患者在治疗后19个月仍存活。动脉内去甲肾上腺素诱导的高血压化疗是胃癌肝转移的有效治疗选择之一。
