Gholami Mohammad Reza, Abolhassani Farid, Pasbakhsh Parichehr, Akbari Mohammad, Sobhani Aligholi, Sohrabi Davood, Mehrania Kobra
Department of Anatomy, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Pak J Biol Sci. 2007 Dec 1;10(23):4256-60. doi: 10.3923/pjbs.2007.4256.4260.
This study evaluated the effectiveness of simvastatin in protecting sciatic nerve from ischemia-reperfusion (I/R) injury using the model of experimental nerve ischemia. Sixty adult male Sprague-Dawley rats weighing 250-300 g were used. They were divided into ten groups (N = 6 per group). We used ischemia model in these groups. All ischemia groups were rendered ischemic for 3 h. Then followed by reperfusion durations of zero time (0 hR), 3 h (3 hR), 7 days (7 dR), 14 days (14 dR). The treatment group received intravenous simvastatin (1 mg kg(-1)) 1 h before ischemia, while the control group received an equal volume of intravenous vehicle at the same time schedule and route. Behavioral data were obtained immediately before euthanasia. The score was based on coordination, racing reflex, toe spread and reaction to pinch. In simvastatin treated I/R rats we had increase in functional recovery. In conclusion, pre-ischemic administration of simvastatin exhibits neuroprotective properties in I/R nerve injury.
本研究采用实验性神经缺血模型，评估辛伐他汀对坐骨神经缺血再灌注（I/R）损伤的保护作用。选用60只体重250 - 300 g的成年雄性Sprague-Dawley大鼠，分为10组（每组n = 6）。对这些组采用缺血模型，所有缺血组均缺血3小时，然后分别进行0小时（0 hR）、3小时（3 hR）、7天（7 dR）、14天（14 dR）的再灌注。治疗组在缺血前1小时静脉注射辛伐他汀（1 mg·kg⁻¹），而对照组在相同时间和途径给予等量的静脉溶媒。在安乐死之前立即获取行为学数据，评分基于协调性、赛跑反射、趾展和对捏的反应。在辛伐他汀治疗的I/R大鼠中，功能恢复有所增加。总之，缺血前给予辛伐他汀对I/R神经损伤具有神经保护作用。
