Li Ai-ping, Zhao Hui, Zhao Zhi, Liu Hong-an, Guo Qin-hua, Li Bo, Guo Kun-feng, Guo Miao, Sun Chang-kai
Department of Physiology, Dalian Medical University, Institute for Brain Diseases of Dalian Medical University, Dalian 116027, China.
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2007 May;23(2):246-51.
To explore the effect of Simvastatin on the regeneration of sciatic nerve with crush injury in rats.
Animals were randomized into the following experimental groups: Simvastatin-treated, vehicle and sham-operated groups. Sciatic nerves with crush injury were performed. After surgery, the functional evaluation of nerve recovery, electrophysiologic assessment, histological assessment, serum IL-6 and lipid were performed.
The toe spread index of Simvastatin-treated rats after operation was higher significantly than vehicle rats at 5 d and 8 d (P<0.05). CMAP was higher and NCV was faster (P < 0.05). The serum IL-6 at 5 d of post-operation was significant lower (P < 0.05). Total serum cholesterol of Simvastatin-treated animals was higher than that of other animals (P < 0.05) at 2 weeks of post-operation. The histological analysis showed that the numbers of myelinated axons and the thickness of myelin sheath of Simvastatin-treated crush injury animals at 4 weeks of post-operation were more than that of vehicle animals.
The present study showed that Simvastatin could promote the regeneration of the sciatic nerve after crush injury in rats, partly through inhibiting immune and inflammatory responses and making the balance of serum cholesterol during these processes.
探讨辛伐他汀对大鼠坐骨神经挤压伤后再生的影响。
将动物随机分为以下实验组：辛伐他汀治疗组、溶剂对照组和假手术组。对坐骨神经进行挤压伤处理。术后进行神经恢复的功能评估、电生理评估、组织学评估、血清白细胞介素-6和血脂检测。
术后5天和8天，辛伐他汀治疗组大鼠的足趾展指数显著高于溶剂对照组大鼠（P<0.05）。复合肌肉动作电位更高，神经传导速度更快（P<0.05）。术后5天时血清白细胞介素-6显著降低（P<0.05）。术后2周，辛伐他汀治疗组动物的血清总胆固醇高于其他组动物（P<0.05）。组织学分析表明，术后4周，辛伐他汀治疗的挤压伤动物的有髓轴突数量和髓鞘厚度均多于溶剂对照组动物。
本研究表明，辛伐他汀可促进大鼠坐骨神经挤压伤后的再生，部分是通过抑制免疫和炎症反应以及在这些过程中维持血清胆固醇平衡来实现的。
