Uziel Daniela, Rozental Renato
Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Epilepsia. 2008 Dec;49 Suppl 9:35-42. doi: 10.1111/j.1528-1167.2008.01925.x.
Maternal epilepsy has a potential for fetal injury, either antiepileptic drug (AED)--induced or as a consequence of seizures per se. The intent of this article is to explore this relationship, discussing similar patterns of malformations seen with AEDs or different disease exposure during pregnancy, and the potential role of gap junctional intercellular communication in abnormal morphogenesis.
母亲癫痫具有造成胎儿损伤的可能性，这要么是由抗癫痫药物（AED）诱发的，要么是癫痫发作本身导致的。本文旨在探讨这种关系，讨论在孕期使用AEDs或接触不同疾病时所见到的相似畸形模式，以及缝隙连接细胞间通讯在异常形态发生中的潜在作用。
