Marsh Eric D, Brooks-Kayal Amy R, Porter Brenda E
Division of Child Neurology and Pediatric Regional Epilepsy Program, Children's Hospital of Philadelphia, and Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Epilepsia. 2006 Dec;47(12):1999-2010. doi: 10.1111/j.1528-1167.2006.00894.x.
Seizures and antiepileptic drugs (AEDs) affect brain development and have long-term neurological consequences. The specific molecular and cellular changes, the precise timing of their influence during brain development, and the full extent of the long-term consequences of seizures and AEDs exposure have not been established. This review critically assesses both the basic and clinical science literature on the effects of seizures and AEDs on the developing brain and finds that evidence exists to support the hypothesis that both seizures and antiepileptic drugs influence a variety of biological process, at specific times during development, which alter long-term cognition and epilepsy susceptibility. More research, both clinical and experimental, is needed before changes in current clinical practice, based on the scientific data, can be recommended.
癫痫发作和抗癫痫药物（AEDs）会影响大脑发育，并产生长期的神经学后果。具体的分子和细胞变化、它们在大脑发育过程中产生影响的确切时间，以及癫痫发作和接触AEDs的长期后果的全部程度尚未明确。本综述批判性地评估了关于癫痫发作和AEDs对发育中大脑影响的基础科学和临床科学文献，发现有证据支持这样的假说，即癫痫发作和抗癫痫药物在发育的特定时期会影响多种生物学过程，进而改变长期认知和癫痫易感性。在基于科学数据建议改变当前临床实践之前，还需要更多的临床和实验研究。
