IRCCS "S.Lucia", Rome, Italy.
Eur J Neurol. 2009 Jan;16(1):81-7. doi: 10.1111/j.1468-1331.2008.02351.x.
Aim of our study was to evaluate cerebral hemodynamic changes during performance of attention tasks and to correlate them with reaction time (RT) and percentage of right answers.
Mean flow velocity (MFV) in middle cerebral arteries was monitored in 30 subjects by transcranial Doppler during tonic alertness, phasic alertness, focused and divided attention tasks.
Mean flow velocity increase was significantly higher during divided attention with respect to other tasks (P < .001). MFV increase was higher in the right than in the left side (P < .001). Asymmetry during attention tasks resulted significantly higher than that observed in tonic alertness condition. RT was increased during focused attention tasks (P < .001 vs. both alert tasks), with further increase during divided attention tasks (P < .001 vs. focused attention task). RT was inversely related to MFV increase only during tonic alertness (P = 0.012 for left side; P = 0.008 for right side). During the divided attention tasks, an association was found between MFV increase and correct answers (r = 0.39, P = 0.033).
These data show a relationship between RT, correct answers and changes in blood flow velocity and suggest that this method of cerebral blood flow investigation could be a useful approach during assessment of patients with attention deficit.
我们研究的目的是评估执行注意任务时的大脑血液动力学变化，并将其与反应时间（RT）和正确答案的百分比相关联。
通过经颅多普勒，在 30 名受试者中监测大脑中动脉的平均血流速度（MFV），在强直警觉、相位警觉、集中和分散注意力任务期间。
与其他任务相比，分散注意力时的平均血流速度增加明显更高（P <.001）。右侧的 MFV 增加高于左侧（P <.001）。注意力任务期间的不对称性明显高于强直警觉状态下观察到的不对称性。在集中注意力任务期间，RT 增加（与两种警觉任务相比，P <.001），在分散注意力任务期间进一步增加（与集中注意力任务相比，P <.001）。仅在强直警觉时，RT 与 MFV 增加呈负相关（左侧 P = 0.012；右侧 P = 0.008）。在分散注意力任务期间，MFV 增加与正确答案之间存在相关性（r = 0.39，P = 0.033）。
这些数据显示 RT、正确答案与血流速度变化之间存在关系，并表明这种脑血流研究方法在评估注意力缺陷患者时可能是一种有用的方法。
