一名患有因子V莱顿突变的女性患者的巨细胞病毒相关性脾梗死：病例报告
Cytomegalovirus-associated splenic infarcts in a female patient with Factor V Leiden mutation: a case report.
作者信息
Atzmony Lihi, Saar Nili, Chundadze Tamar, Arbel Yaron, Justo Dan, Mashav Noa
机构信息
Department of Internal Medicine D, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.
出版信息
J Med Case Rep. 2008 Dec 16;2:385. doi: 10.1186/1752-1947-2-385.
INTRODUCTION
Cytomegalovirus-associated thrombosis has rarely been reported in the medical literature, and if so, mainly in immunocompromized patients.
CASE PRESENTATION
We report the case of a 36-year-old Caucasian woman with acute cytomegalovirus infection presenting with spontaneous splenic infarcts. Trans-esophageal echocardiography did not show any vegetations or mural thrombi. The patient was also found to be heterozygous for the Factor V Leiden mutation. Anticoagulation treatment was considered but ruled out since cytomegalovirus was the obvious trigger for thrombosis in this patient. To the best of our knowledge, this is only the third report to date of cytomegalovirus-associated splenic infarcts.
CONCLUSION
This case report serves as additional evidence for the role of cytomegalovirus in thrombosis.
引言
巨细胞病毒相关性血栓形成在医学文献中鲜有报道，即便有报道，也主要见于免疫功能低下的患者。
病例报告
我们报告一例36岁的白种女性，患有急性巨细胞病毒感染，表现为自发性脾梗死。经食管超声心动图未显示任何赘生物或壁血栓。该患者还被发现存在凝血因子V莱顿突变杂合子。考虑过抗凝治疗，但由于巨细胞病毒是该患者血栓形成的明显诱因，故排除该治疗。据我们所知，这是迄今为止关于巨细胞病毒相关性脾梗死的第三例报告。
结论
本病例报告为巨细胞病毒在血栓形成中的作用提供了更多证据。
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