Squizzato Alessandro, Gerdes Victor E A, Büller Harry R
Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.
Thromb Haemost. 2005 Mar;93(3):403-10. doi: 10.1160/TH04-08-0523.
Pathophysiological mechanisms of acute vascular thrombosis are not fully understood. It has been suggested that different infectious pathogens are responsible agents of thrombotic disorders. The infection hypothesis is supported by an increasing number of reports on the interaction between acute infection and coagulation. Cytomegalovirus (CMV) is supposed to play an important role in apparently unprovoked thrombosis. We reviewed all human in vitro and in vivo studies on the influence of human CMV infection on the coagulation system, as well as all case reports of acute thrombosis during acute human CMV infection. In the published literature there is mounting evidence that human CMV may play a role in thrombotic disorders. Definitive conclusions, however, cannot be drawn, although the in vitro studies are convincing and offer insight in the pathogenesis.
急性血管血栓形成的病理生理机制尚未完全明确。有观点认为，不同的感染性病原体是血栓形成性疾病的致病因素。急性感染与凝血之间相互作用的报告越来越多，这支持了感染假说。巨细胞病毒（CMV）被认为在明显无诱因的血栓形成中起重要作用。我们回顾了所有关于人巨细胞病毒感染对凝血系统影响的人体体外和体内研究，以及急性人巨细胞病毒感染期间急性血栓形成的所有病例报告。在已发表的文献中，越来越多的证据表明人巨细胞病毒可能在血栓形成性疾病中起作用。然而，尽管体外研究很有说服力并为发病机制提供了见解，但仍无法得出明确结论。
