Goren M P, Lyman B A, Li J T
Department of Pathology and Laboratory Medicine, St. Jude Children's Research Hospital, Memphis, TN 38101-0318.
Cancer Chemother Pharmacol. 1991;28(4):298-301. doi: 10.1007/BF00685538.
We evaluated the stability of the aqueous formulation of mesna during storage in syringes and after dilution in beverages and syrups. Measurements of the concentrations of mesna showed that the undiluted formulation was stable for at least 9 days in standard polypropylene syringes at 5 degrees, 24 degrees, and 35 degrees C. There was no detectable oxidation of mesna to dimesna over the course of at least 1 week when mesna was diluted 1:2 and 1:5 in syrups and incubated at 24 degrees C in capped tubes. Concentration changes were clinically negligible for 1:2, 1:10, and 1:100 dilutions of mesna in six carbonated drinks, two juices, and milk after incubation for 24 h at 5 degrees C. Thus, the aqueous mesna formulation is stable when diluted and stored in a variety of beverages and syrups under conditions suitable for oral administration.
我们评估了美司钠水性制剂在注射器中储存期间以及在饮料和糖浆中稀释后的稳定性。美司钠浓度的测量结果表明，未稀释的制剂在5℃、24℃和35℃的标准聚丙烯注射器中至少9天内是稳定的。当美司钠在糖浆中按1:2和1:5稀释并在24℃的带帽试管中孵育时，在至少1周的时间内未检测到美司钠氧化为二巯基丁二酸钠。美司钠在六种碳酸饮料、两种果汁和牛奶中按1:2、1:10和1:100稀释后，在5℃孵育24小时后，浓度变化在临床上可忽略不计。因此，美司钠水性制剂在适合口服给药的条件下稀释并储存在各种饮料和糖浆中时是稳定的。
